{"id":"W2502173943","doi":"10.1007/978-1-4939-3798-1_2","title":"Structure and Function of G-Protein-Coupled Receptor Kinases 1 and 7","year":2016,"lang":"en","type":"book-chapter","venue":"Methods in pharmacology and toxicology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Health Canada; National Institutes of Health; Foundation Fighting Blindness; Arnold and Mabel Beckman Foundation","keywords":"G protein-coupled receptor kinase; G protein-coupled receptor; Rhodopsin; Beta adrenergic receptor kinase; Kinase; Rhodopsin-like receptors; Biology; Cell biology; Arrestin; Receptor; Signal transduction; Biochemistry; Agonist; Retinal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364718,0.0006289671,0.0003372991,0.0002853895,0.0003406417,0.0007399974,0.0008280562,0.0006805255,0.002669337],"category_scores_gemma":[0.000181015,0.0003295003,0.0003449329,0.0002441525,0.0006788287,0.001018872,0.0003186107,0.002007207,0.00268646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008323654,"about_ca_system_score_gemma":0.0007316539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004203754,"about_ca_topic_score_gemma":0.000596237,"domain_scores_codex":[0.9999241,0.00001040178,0.000003072273,0.00001347673,0.0000339662,0.00001500442],"domain_scores_gemma":[0.999972,0.000007865559,0.000005477436,0.000002902516,0.0000062447,0.000005515113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003677654,0.0001142368,0.0001949032,0.001077288,0.00002352748,0.0004018905,0.0004007556,0.005320325,0.2128117,0.474306,0.03660014,0.2683814],"study_design_scores_gemma":[0.00003070413,0.0001315342,0.0007372075,0.0001930985,0.00002222318,0.0008312807,0.00008892122,0.002089604,0.06857762,0.1057934,0.8214621,0.00004231045],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.07547218,0.6486033,0.04880768,0.01245122,0.006665755,0.0001100087,0.0009117086,0.0005358902,0.2064422],"genre_scores_gemma":[0.2331046,0.4900621,0.0420346,0.003314057,0.002144934,0.0002244845,0.002002666,0.0001997176,0.2269128],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002669337,"threshold_uncertainty_score":0.008929789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794255663203784,"score_gpt":0.3254241434038041,"score_spread":0.3074815867717663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}