{"id":"W2502396874","doi":"10.1093/biolreprod/85.s1.274","title":"Paternal Exposure to Cyclophosphamide Leads to a Dampened DNA Repair Response and Enhanced DNA Damage in 8-Cell Embryos.","year":2011,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biology; DNA repair; DNA damage; Nucleotide excision repair; Aphidicolin; Poly ADP ribose polymerase; Molecular biology; Base excision repair; Zygote; DNA repair protein XRCC4; Embryo; Andrology; DNA; Cell biology; Genetics; DNA polymerase; Polymerase; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039338,0.000320846,0.0001539111,0.0002737984,0.0001112041,0.0001953496,0.0002274626,0.0002885462,0.002131812],"category_scores_gemma":[0.0001013472,0.0002475124,0.0001925184,0.00008679562,0.0001846361,0.0001238632,0.0001609116,0.000589261,0.0004510734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002683413,"about_ca_system_score_gemma":0.000169532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007369835,"about_ca_topic_score_gemma":0.001890599,"domain_scores_codex":[0.9998744,0.00002070937,0.00001045613,0.00003942264,0.00003191331,0.00002307705],"domain_scores_gemma":[0.9998263,0.00002459215,0.00006668959,0.00002072602,0.00001488283,0.00004677263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095153,0.0000204758,0.0005330896,0.00001666331,0.000004093895,0.0001324578,0.00001091807,0.00001145593,0.9981286,0.00005081244,0.00002059255,0.0009614101],"study_design_scores_gemma":[0.00001660161,0.0009772452,0.03211296,0.00001344902,0.0000289834,0.001039538,0.00004509392,0.0001999366,0.9630823,0.00004019597,0.002437105,0.000006490945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994787,0.001307425,0.00160492,0.000062856,0.00003165231,0.00002593869,0.0005149166,0.0000569426,0.001608347],"genre_scores_gemma":[0.9870858,0.001218545,0.001989934,0.00005881517,0.000007193391,0.00004426061,0.0008540681,0.00002242929,0.00871905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131812,"threshold_uncertainty_score":0.007131636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02320481304419656,"score_gpt":0.2718166917715438,"score_spread":0.2486118787273473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}