{"id":"W2502954110","doi":"10.1038/ncomms12188","title":"LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; McGill University; National Institutes of Health; Buck Institute for Research on Aging; Glenn Foundation for Medical Research","keywords":"LRRK2; Synaptic vesicle; Postsynaptic potential; Cell biology; Synaptic plasticity; Neuromuscular junction; Biology; Neuroscience; Neurotransmission; Endocytic cycle; Neurotransmitter; Postsynaptic density; Synaptic vesicle recycling; Endocytosis; Excitatory postsynaptic potential; Inhibitory postsynaptic potential; Gene; Biochemistry; Central nervous system; Vesicle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008034586,0.0003460968,0.0002163531,0.0001865942,0.0002457218,0.0003193707,0.0001761823,0.000258837,0.0006998759],"category_scores_gemma":[0.00007873653,0.0001221869,0.0001834514,0.00007885968,0.0002124348,0.0002169222,0.0002790382,0.0003530513,0.0004085368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004885549,"about_ca_system_score_gemma":0.0001830947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007483838,"about_ca_topic_score_gemma":0.001795604,"domain_scores_codex":[0.9999114,0.00001167954,0.000008364963,0.00002057799,0.00002613868,0.00002181225],"domain_scores_gemma":[0.999921,0.000005763279,0.00002695823,0.000007128479,0.00001459554,0.0000246256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002517755,0.00000383236,0.000161854,0.000008426839,0.000001752405,0.0000727285,0.000005494389,0.00004956154,0.999244,0.00009613208,0.00002462144,0.0003064537],"study_design_scores_gemma":[0.00001276332,0.00006402132,0.01560451,0.000005760891,0.000011488,0.0003373109,0.00003752623,0.001701456,0.981075,0.0001041931,0.001041104,0.000004971126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960141,0.0007518749,0.001290048,0.00006637744,0.00001620816,0.000006179601,0.0001081615,0.00006799632,0.001679032],"genre_scores_gemma":[0.997056,0.0003370352,0.0006676578,0.00002790022,0.000004493742,0.000008129025,0.0001043272,0.0000196953,0.001774851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007483838,"threshold_uncertainty_score":0.003544688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01177587111128841,"score_gpt":0.2400039237596858,"score_spread":0.2282280526483974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}