{"id":"W2503844450","doi":"10.1093/toxsci/kfw089","title":"Editor's Highlight: Hydroxyurea Exposure Activates the P53 Signaling Pathway in Murine Organogenesis-Stage Embryos","year":2016,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Embryo; Teratology; Biology; DNA damage; Transcriptome; Oxidative stress; Downregulation and upregulation; Signal transduction; Organogenesis; Embryogenesis; Andrology; Western blot; Cell biology; Molecular biology; Gene expression; Gene; Fetus; Endocrinology; Genetics; DNA; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007801033,0.0001421114,0.000127087,0.00003663072,0.0002154186,0.00004591328,0.0004209102,0.0001757054,0.0001733966],"category_scores_gemma":[0.0003165035,0.00006407595,0.00005684205,0.0002317562,0.0003442247,0.000009685616,0.0001499267,0.00006251934,0.0000146219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001859872,"about_ca_system_score_gemma":0.00006764678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001064141,"about_ca_topic_score_gemma":0.00005037762,"domain_scores_codex":[0.9986303,0.0001564353,0.0002196787,0.0004174669,0.0002450186,0.0003311016],"domain_scores_gemma":[0.9994562,0.000148561,0.00009140758,0.0001924769,0.00003802467,0.00007329888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001607654,0.00005802357,0.01447193,0.000001870148,0.000004153476,0.000002447253,0.00001993634,0.0001087997,0.9823722,0.0002181622,0.00009963671,0.002626751],"study_design_scores_gemma":[0.0002239556,0.0005658651,0.01477416,0.000009046701,0.000002069207,6.012883e-7,0.00005573341,0.00001307816,0.9536103,0.0005060438,0.03009486,0.0001443155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957696,0.0006888445,0.000335977,0.001537707,0.0005232037,0.0001654512,0.000007719472,0.00001565165,0.0009558373],"genre_scores_gemma":[0.997521,0.0001562766,0.0002128886,0.0001542883,0.001168263,0.00002658317,0.000003578817,0.00000645709,0.0007506658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02999523,"threshold_uncertainty_score":0.2612942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005364728773819,"score_gpt":0.2627188143491655,"score_spread":0.2426651670614273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}