{"id":"W2503894506","doi":"10.1093/hmg/ddw234","title":"Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Krembil Foundation; Huntington Society of Canada; CHDI Foundation","keywords":"Huntingtin; Polyglutamine tract; Phosphorylation; Huntingtin Protein; Biology; Mutant; Endoplasmic reticulum; Reactive oxygen species; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006332611,0.0001775344,0.0001315951,0.00009451128,0.0001358476,0.0001274015,0.0001362889,0.0001700121,0.000645461],"category_scores_gemma":[0.00006039658,0.00007293942,0.000135154,0.00009426034,0.000144129,0.00009943698,0.0001286168,0.0001371071,0.0003346357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001738323,"about_ca_system_score_gemma":0.00009059707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004102026,"about_ca_topic_score_gemma":0.0004708987,"domain_scores_codex":[0.9999653,0.000004563956,0.000002461363,0.00001014587,0.00001030046,0.000007164617],"domain_scores_gemma":[0.9999435,0.00000663315,0.0000232638,0.00000376819,0.000008437911,0.00001443481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007175544,0.000008873243,0.0006895434,0.00002688836,0.000003025169,0.00009769123,0.00001194111,0.0000410998,0.9978595,0.00005569066,0.00004228391,0.001091686],"study_design_scores_gemma":[0.00001283658,0.000167203,0.01982233,0.00001104891,0.00001191752,0.0009831589,0.00004842216,0.0008762398,0.9718013,0.0001403122,0.006117595,0.000007615836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948443,0.001753053,0.00201575,0.00004675368,0.00001773088,0.00001301527,0.0002580442,0.00003197822,0.001019179],"genre_scores_gemma":[0.9936218,0.000847634,0.002532714,0.0000552585,0.000007716294,0.00001208272,0.0007202526,0.00001086471,0.002191803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000645461,"threshold_uncertainty_score":0.002159297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353814845672624,"score_gpt":0.2543842243108828,"score_spread":0.2308460758541565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}