{"id":"W2503894506","doi":"10.1093/hmg/ddw234","title":"Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Krembil Foundation; Huntington Society of Canada; CHDI Foundation","keywords":"Huntingtin; Polyglutamine tract; Phosphorylation; Huntingtin Protein; Biology; Mutant; Endoplasmic reticulum; Reactive oxygen species; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001623863,0.0003176846,0.0002277982,0.0001395261,0.0004610227,0.0001488418,0.0002103092,0.00009801515,0.0001020626],"category_scores_gemma":[0.0004983137,0.0002854611,0.0000860818,0.0002627937,0.000307419,0.00009214821,0.0001974665,0.00009235709,0.00003271687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005294305,"about_ca_system_score_gemma":0.00004275206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006307956,"about_ca_topic_score_gemma":0.000005013176,"domain_scores_codex":[0.9974385,0.0003139777,0.0004210251,0.0008889179,0.0005076621,0.0004299173],"domain_scores_gemma":[0.9987714,0.0001265934,0.0003012306,0.000505077,0.0001497338,0.0001459277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001551728,0.00004082303,0.004863495,0.00001560338,0.000007740512,0.00001287469,0.0004982883,0.0001140832,0.9907168,0.002355114,0.0001512861,0.001208347],"study_design_scores_gemma":[0.0006247081,0.0000932546,0.03571513,0.0000562466,0.00003160984,0.00001000142,0.0001157705,0.0003447098,0.9567348,0.004269949,0.001645458,0.0003583794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810737,0.0001280674,0.01614427,0.0002747924,0.00007980539,0.0004444359,0.00003726032,0.00009258831,0.001725075],"genre_scores_gemma":[0.9953992,0.00004498217,0.002685328,0.0009215618,0.0001072475,0.0000223501,0.000009791615,0.00007908489,0.0007304939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03398204,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353814845672624,"score_gpt":0.2543842243108828,"score_spread":0.2308460758541565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}