{"id":"W2503901518","doi":"10.1016/j.bpj.2015.11.1565","title":"Functional and Structural Characterization of the GluK2/GluK5 Heterotetramer Gating Mechanism","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Kainate receptor; Homomeric; Heterotetramer; AMPA receptor; Biophysics; Ionotropic effect; Kainic acid; Ion channel; Glutamate receptor; Ionotropic glutamate receptor; Chemistry; Biology; Receptor; Biochemistry; Protein subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002029494,0.0002514345,0.0002151586,0.0001051022,0.0002777787,0.0003608791,0.0003404339,0.0003680703,0.001829076],"category_scores_gemma":[0.000218761,0.0001015216,0.0002569751,0.0001232081,0.0002133006,0.0003140901,0.0001725717,0.0005049009,0.0004575379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004674225,"about_ca_system_score_gemma":0.0002109862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007990264,"about_ca_topic_score_gemma":0.000607856,"domain_scores_codex":[0.9998984,0.000012135,0.00001244703,0.00002744556,0.00002561597,0.0000239332],"domain_scores_gemma":[0.999903,0.00001554004,0.00002520838,0.00001514236,0.00001177096,0.00002939201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001655079,0.00002689514,0.0002260346,0.00001773103,0.000006056035,0.00009872789,0.00001982449,0.0002011872,0.9977715,0.0004612154,0.00006467666,0.0009407085],"study_design_scores_gemma":[0.00003662588,0.000129861,0.007550213,0.000008650366,0.00002986143,0.000845624,0.00007889047,0.01043464,0.9783216,0.0002513267,0.002294386,0.00001825831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953619,0.0003228348,0.002794657,0.0001401783,0.00003175081,0.00001310651,0.0002457274,0.00003888966,0.001051073],"genre_scores_gemma":[0.9973481,0.0001149649,0.001210485,0.00006854619,0.000005862113,0.000009034254,0.0003462361,0.00001700861,0.0008797851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829076,"threshold_uncertainty_score":0.006118894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04139727017514219,"score_gpt":0.2981663770242341,"score_spread":0.2567691068490919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}