{"id":"W2504168572","doi":"10.1158/1538-7445.am2016-lb-051","title":"Abstract LB-051: Cancer cell binding, internalization and intracellular localization of a novel therapeutic peptide SOR-C13 targeting the TRPV6 oncochannel","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Industries (Canada)","funders":"","keywords":"Internalization; TRPV6; Peptide; Intracellular; Endocytosis; Cell; Cell-penetrating peptide; Cancer research; Biology; Chemistry; Cell biology; Biochemistry; Internal medicine; Medicine; Calcium; Calcium metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131256,0.0002380339,0.0002522916,0.0001200243,0.0001539217,0.000177279,0.0002261187,0.0002853155,0.001770916],"category_scores_gemma":[0.00008123848,0.00007730952,0.000203363,0.0001354479,0.000128181,0.0001198014,0.0001056833,0.0004304871,0.000489012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004478329,"about_ca_system_score_gemma":0.0002845087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592721,"about_ca_topic_score_gemma":0.001031208,"domain_scores_codex":[0.9998932,0.00001762815,0.000005761619,0.00002050783,0.00003078315,0.00003213692],"domain_scores_gemma":[0.9999579,0.000009025068,0.000006353557,0.00000455331,0.000009235207,0.00001302838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001934188,0.00005734586,0.00005974758,0.00003144542,0.000002903491,0.00003070703,0.000005502181,0.00009548984,0.9984038,0.00005177892,0.00008383718,0.0009839542],"study_design_scores_gemma":[0.00002923725,0.0006367337,0.001664224,0.000003258208,0.000008291325,0.0001751751,0.00001011101,0.001606442,0.9942995,0.00001265761,0.001550584,0.000003612435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916537,0.001354985,0.003231902,0.00008694752,0.00002910197,0.00006438201,0.0005796868,0.00008238725,0.002916906],"genre_scores_gemma":[0.9896126,0.0005795219,0.004368687,0.00006311331,0.000007310202,0.00005998229,0.001265004,0.00002031299,0.004023395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001770916,"threshold_uncertainty_score":0.005924284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05064239758158065,"score_gpt":0.3294075394018077,"score_spread":0.278765141820227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}