{"id":"W2504181072","doi":"10.1158/2159-8290.cd-15-1227","title":"Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types","year":2016,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; Public Health Ontario; McGill University and Génome Québec Innovation Centre","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute for Health and Care Research; Ovarian Cancer Research Fund; National Institutes of Health; Cancer Research UK; Francis Crick Institute; U.S. Department of Defense; Breast Cancer Research Foundation; World Health Organization; Roswell Park Cancer Institute","keywords":"Prostate cancer; Genome-wide association study; Ovarian cancer; Breast cancer; Biology; Cancer; Computational biology; Genetic association; Genetics; Prostate; Genome; Bioinformatics; Oncology; Medicine; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008344755,0.002238221,0.003751462,0.003288206,0.0006893336,0.002531508,0.001688648,0.001219017,0.003099342],"category_scores_gemma":[0.01033782,0.000701401,0.01382578,0.00550397,0.00061325,0.0007307495,0.001739937,0.001416778,0.0002858143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006621126,"about_ca_system_score_gemma":0.0008547991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004298768,"about_ca_topic_score_gemma":0.006415026,"domain_scores_codex":[0.9950458,0.00182789,0.0005917517,0.001635486,0.0005652212,0.0003337956],"domain_scores_gemma":[0.9920621,0.004551204,0.001373964,0.001343718,0.0004101521,0.0002588764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004409777,0.0000499082,0.5552636,0.003568657,0.4099191,0.000633601,0.000122441,0.00206822,0.005168294,0.0004414977,0.001380184,0.01697469],"study_design_scores_gemma":[0.000617404,0.0004828621,0.5408164,0.0006596325,0.4442188,0.001487689,0.000198394,0.003195934,0.002696731,0.001631787,0.003937865,0.00005647678],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6699705,0.2973244,0.01809505,0.002299018,0.0006772251,0.0001337453,0.008727126,0.0008551732,0.001917896],"genre_scores_gemma":[0.9827037,0.01187034,0.002619565,0.0002940503,0.0001728926,0.0000666772,0.001979319,0.00006868212,0.0002247132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008344755,"threshold_uncertainty_score":0.04413182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06243794438319494,"score_gpt":0.3644030428553883,"score_spread":0.3019650984721933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}