{"id":"W2504181072","doi":"10.1158/2159-8290.cd-15-1227","title":"Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types","year":2016,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; BC Cancer Agency; Public Health Ontario; McGill University and Génome Québec Innovation Centre","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; Medical Research Council; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institute for Health and Care Research; Ovarian Cancer Research Fund; National Institutes of Health; Cancer Research UK; Francis Crick Institute; U.S. Department of Defense; Breast Cancer Research Foundation; World Health Organization; Roswell Park Cancer Institute","keywords":"Prostate cancer; Genome-wide association study; Ovarian cancer; Breast cancer; Biology; Cancer; Computational biology; Genetic association; Genetics; Prostate; Genome; Bioinformatics; Oncology; Medicine; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003666354,0.0002365017,0.0006114426,0.00003212833,0.0001046795,0.00002417557,0.0001370468,0.0001381128,0.0002365964],"category_scores_gemma":[0.0004931946,0.0001593931,0.0002240632,0.0001006912,0.0001249541,0.00002948793,0.0001677863,0.00005703929,0.000003220411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961009,"about_ca_system_score_gemma":0.0002501556,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006852187,"about_ca_topic_score_gemma":0.01687679,"domain_scores_codex":[0.9983009,0.0001777638,0.0004480359,0.0005609358,0.0001690506,0.0003432782],"domain_scores_gemma":[0.9986063,0.0001722558,0.0005410141,0.0002942475,0.0002960548,0.00009011613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008839164,0.00002102006,0.6174104,0.0000290023,0.003929942,1.809023e-7,0.00008109385,0.0002993745,0.3524826,9.803165e-7,0.02464241,0.001014625],"study_design_scores_gemma":[0.001679133,0.00007011204,0.917444,0.00003595067,0.002656514,0.000001112384,0.0001232219,0.00001363259,0.06531011,0.0001959234,0.0120794,0.0003908736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9325789,0.0598809,0.0003822019,0.003602299,0.0001924818,0.000257535,0.003067709,0.000008120095,0.00002982235],"genre_scores_gemma":[0.9612753,0.0166625,0.0000784945,0.0003319405,0.0002317766,0.0001909987,0.0001422004,0.00002338296,0.02106339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000337,"threshold_uncertainty_score":0.9997613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06243794438319494,"score_gpt":0.3644030428553883,"score_spread":0.3019650984721933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}