{"id":"W2504623699","doi":"10.1016/s1470-2045(16)30167-x","title":"Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial","year":2016,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":924,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; BC Cancer Agency; University of Toronto","funders":"NIHR Oxford Biomedical Research Centre; National Institutes of Health; National Cancer Institute; National Institute for Health and Care Research; Bristol-Myers Squibb","keywords":"Brentuximab vedotin; Medicine; Nivolumab; Internal medicine; Oncology; Autologous stem-cell transplantation; Clinical endpoint; Transplantation; Lymphoma; Surgery; Clinical trial; Hodgkin lymphoma; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002077141,0.001779722,0.002672268,0.0003365287,0.0004215114,0.001360982,0.0008265986,0.001390914,0.002361675],"category_scores_gemma":[0.001109138,0.0005628341,0.001983514,0.0003374641,0.001215439,0.001496787,0.0004482677,0.003042507,0.0008402747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001320104,"about_ca_system_score_gemma":0.001136345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009131656,"about_ca_topic_score_gemma":0.002685826,"domain_scores_codex":[0.9993876,0.0003120964,0.00002351117,0.0001010349,0.00004079352,0.000134974],"domain_scores_gemma":[0.9993986,0.0001315174,0.00008807069,0.00006753799,0.00003684324,0.0002775035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9302389,0.006725245,0.002537667,0.0005300156,0.002239383,0.000089998,0.00013047,0.001307341,0.004449062,0.0001808214,0.001321186,0.05025004],"study_design_scores_gemma":[0.8980363,0.09297341,0.004916655,0.00004728682,0.0008084361,0.0001179754,0.00006824098,0.0008063967,0.0006696063,0.0003920564,0.001128558,0.0000350888],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938574,0.003193039,0.0003813083,0.0004102071,0.0002510672,0.0006552062,0.0004031572,0.0000668402,0.0007818109],"genre_scores_gemma":[0.9944713,0.0013539,0.0007964328,0.000636385,0.000123975,0.0006530614,0.0006384893,0.00002050881,0.001305955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002672268,"threshold_uncertainty_score":0.01098514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03356002623975395,"score_gpt":0.3124283474722595,"score_spread":0.2788683212325055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}