{"id":"W2504632565","doi":"10.1158/1538-7445.am2016-2521","title":"Abstract 2521: STAT3 is a central regulator of proliferation, invasion and metabolism in GBM tumor initiating cells","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Cancer research; STAT3; Biology; STAT protein; Glioma; Cell growth; Cell culture; Gene signature; Regulator; Gene expression; Signal transduction; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001046161,0.0004043552,0.0003150489,0.0004928316,0.0003002082,0.0004665207,0.0001717807,0.0002255284,0.005272618],"category_scores_gemma":[0.0001053497,0.0001224022,0.0003530773,0.001027165,0.0001723634,0.0001657316,0.000158844,0.0004633167,0.001912909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004654657,"about_ca_system_score_gemma":0.0003703679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097894,"about_ca_topic_score_gemma":0.002110312,"domain_scores_codex":[0.999841,0.000009570852,0.00001352913,0.00003088342,0.00007805258,0.00002690093],"domain_scores_gemma":[0.9999301,0.000008585571,0.00002279236,0.000006251648,0.00001826983,0.00001406616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005329154,0.00004407168,0.002842824,0.0001760584,0.00002030075,0.0001008944,0.00001440537,0.0002246166,0.9878998,0.0001710921,0.001752089,0.00622104],"study_design_scores_gemma":[0.00007933206,0.0004223015,0.1575865,0.00003950892,0.0001032398,0.001207932,0.00008659642,0.003693172,0.8096499,0.0004609272,0.02664634,0.00002430432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.908152,0.01086873,0.007766327,0.0006885331,0.0002543613,0.0001100351,0.0620048,0.0009680548,0.009187066],"genre_scores_gemma":[0.8907344,0.004446959,0.004721167,0.0003641801,0.000063784,0.0001246813,0.08929811,0.0001012121,0.01014545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005272618,"threshold_uncertainty_score":0.01763868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03791412548071164,"score_gpt":0.3366640931762896,"score_spread":0.298749967695578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}