{"id":"W2504926893","doi":"10.1053/j.gastro.2016.06.051","title":"A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition","year":2016,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; University of Toronto; Mount Sinai Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Agency for Healthcare Research and Quality; National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Center for Advancing Translational Sciences; Crohn's and Colitis Foundation","keywords":"Inflammatory bowel disease; Ulcerative colitis; Missense mutation; Genome-wide association study; Disease; Crohn's disease; Microbiome; Biology; Genetics; Medicine; Bioinformatics; Gene; Single-nucleotide polymorphism; Mutation; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007974081,0.0001727441,0.0001539461,0.00007693631,0.00005824773,0.00001366072,0.00009911422,0.00009030774,0.00003436541],"category_scores_gemma":[0.00001886355,0.0001334311,0.00004284237,0.00002878653,0.00018915,0.000006167534,0.00008289247,0.00005454777,0.000007262423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003691759,"about_ca_system_score_gemma":0.00003011261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009622614,"about_ca_topic_score_gemma":0.0002493768,"domain_scores_codex":[0.9988272,0.0001649199,0.000192016,0.0003895678,0.00006223658,0.0003641225],"domain_scores_gemma":[0.9994287,0.000006520327,0.00008918055,0.0002622179,0.00004889342,0.000164461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002478128,0.0001837782,0.3937405,0.00001610178,0.0001060165,0.003544661,0.00003218117,0.000003062666,0.5990634,0.00004676054,0.0007594579,0.00002592779],"study_design_scores_gemma":[0.003445461,0.0003481319,0.9951198,0.00005390366,0.00004029403,0.0001214877,0.000004617655,0.000007486593,0.0006140549,0.00003832583,0.00009161029,0.0001147955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987044,0.00002443535,0.0003069955,0.0005550151,0.00003694729,0.0002031715,0.0001383521,0.00001451006,0.00001622056],"genre_scores_gemma":[0.9985272,0.000009009475,0.00007600285,0.001064361,0.00004970385,0.00002952208,0.0001070685,0.00002216244,0.0001150224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6013793,"threshold_uncertainty_score":0.544116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004587994062445025,"score_gpt":0.2068601322816218,"score_spread":0.2022721382191768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}