{"id":"W2504926893","doi":"10.1053/j.gastro.2016.06.051","title":"A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition","year":2016,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; University of Toronto; Mount Sinai Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Agency for Healthcare Research and Quality; National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Center for Advancing Translational Sciences; Crohn's and Colitis Foundation","keywords":"Inflammatory bowel disease; Ulcerative colitis; Missense mutation; Genome-wide association study; Disease; Crohn's disease; Microbiome; Biology; Genetics; Medicine; Bioinformatics; Gene; Single-nucleotide polymorphism; Mutation; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002713791,0.001319625,0.0007478775,0.001259371,0.001127815,0.0004608296,0.0005968337,0.002150081,0.003899519],"category_scores_gemma":[0.001781318,0.000282929,0.0008123941,0.001398375,0.0008080852,0.000315677,0.0005618334,0.0006974549,0.0004404818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942202,"about_ca_system_score_gemma":0.0002768565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002160633,"about_ca_topic_score_gemma":0.002476242,"domain_scores_codex":[0.9994864,0.00009948987,0.00008641901,0.0001559801,0.0001053845,0.00006639789],"domain_scores_gemma":[0.9986243,0.0004005319,0.0005453532,0.00007393376,0.00008802327,0.0002679012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007942963,0.0003562849,0.4205165,0.0002823721,0.00100914,0.2758209,0.001060865,0.0005767876,0.2778687,0.001108392,0.001743819,0.01171337],"study_design_scores_gemma":[0.0003170233,0.0008748478,0.7451456,0.0001384993,0.0008149984,0.2313021,0.0006537334,0.002310628,0.01357471,0.001139363,0.003617515,0.0001108863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977016,0.0003559764,0.0004658486,0.0003202173,0.00007568795,0.00001134642,0.0003885551,0.00003466863,0.0006461875],"genre_scores_gemma":[0.9989614,0.0000657788,0.0004017995,0.0000743232,0.0000465673,0.000005563671,0.0001322013,0.00001475272,0.0002976346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003899519,"threshold_uncertainty_score":0.01304519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004587994062445025,"score_gpt":0.2068601322816218,"score_spread":0.2022721382191768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}