{"id":"W2505019684","doi":"10.1371/journal.pgen.1006192","title":"Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; FP7 People: Marie-Curie Actions; Canadian Institutes of Health Research","keywords":"Polysome; Biology; RNA; Stress granule; Cell biology; FMR1; Protein biosynthesis; Population; Soma; Messenger RNA; Fragile X syndrome; RNA-binding protein; Translation (biology); Genetics; Fragile x; Neuroscience; Ribosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000963299,0.0001734731,0.0001353505,0.00004434914,0.0001207468,0.00004483707,0.0001572002,0.00008703819,0.0000122843],"category_scores_gemma":[0.00004847312,0.0001220861,0.00003884679,0.00008973842,0.0000919294,0.000007382877,0.0001380423,0.00006718912,0.000003832646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001238216,"about_ca_system_score_gemma":0.00002870051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009763327,"about_ca_topic_score_gemma":0.0001375768,"domain_scores_codex":[0.9988184,0.00009123461,0.0002866639,0.0003527596,0.0001967777,0.0002541763],"domain_scores_gemma":[0.9995741,0.00001969034,0.00008284607,0.0002197349,0.00003679786,0.00006678558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004187502,0.0000338293,0.05368511,0.00001097655,0.0000267668,8.555078e-7,0.0001179818,0.000009068764,0.925281,0.00001879565,0.00002423035,0.0207495],"study_design_scores_gemma":[0.0009938055,0.0002040046,0.4117419,0.00003459412,0.00001883401,0.00000213678,0.00005674238,0.0001626656,0.5847899,0.0004491976,0.001327911,0.0002183424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962562,0.0004739258,0.00004244563,0.002625203,0.00003857023,0.0004699449,0.0000467759,0.00001232798,0.00003455209],"genre_scores_gemma":[0.9988303,0.0002994755,0.0004813925,0.0001131096,0.0000746433,0.00003985983,0.00008117433,0.00003012521,0.00004988243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3580567,"threshold_uncertainty_score":0.4978529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767781257038315,"score_gpt":0.2269495725812362,"score_spread":0.209271760010853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}