{"id":"W2505439876","doi":"10.1371/journal.ppat.1005772","title":"Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Canadian Liver Foundation; Foundation Fighting Blindness","keywords":"RNA Helicase A; RIG-I; Small nuclear RNA; RNA; Gene knockdown; Biology; Spliceosome; RNA-dependent RNA polymerase; Virology; RNA silencing; Sendai virus; Cell biology; IRF3; Helicase; RNA splicing; RNA interference; Virus; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002908334,0.0001568409,0.0002569577,0.0001535444,0.00009665086,0.000008110948,0.00008197708,0.0001686474,0.0001060656],"category_scores_gemma":[0.0004734419,0.000108788,0.00006564954,0.00007184287,0.00024034,0.000130987,0.00007645203,0.0001066736,0.0001271245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002846789,"about_ca_system_score_gemma":0.00004653789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001274267,"about_ca_topic_score_gemma":0.000001261521,"domain_scores_codex":[0.9986882,0.0005061043,0.0002576215,0.0002379919,0.00003758246,0.0002724866],"domain_scores_gemma":[0.9991245,0.0004158449,0.000126957,0.0002365287,0.00008100549,0.00001511278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002946924,0.00007872417,0.0006250651,0.00001526397,0.00008607374,0.000005247546,0.0004241618,1.85537e-8,0.974493,0.0001102701,0.00005733198,0.02115795],"study_design_scores_gemma":[0.0009051474,0.0004964232,0.01321849,0.0001799666,0.00003041263,0.00003590367,0.0001025482,0.000005914938,0.9839157,0.00007298822,0.0008858624,0.0001505939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983684,0.0002496472,0.0002622755,0.0004262549,0.0001257665,0.0001824891,0.00006003718,0.00005252358,0.0002725617],"genre_scores_gemma":[0.9974504,0.00004219845,0.0001411298,0.00005442242,0.00001771174,0.000003011674,0.000007875419,0.00001949815,0.002263733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02100735,"threshold_uncertainty_score":0.4436245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520897043279391,"score_gpt":0.2316488341016121,"score_spread":0.2164398636688182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}