{"id":"W2505439876","doi":"10.1371/journal.ppat.1005772","title":"Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Canadian Liver Foundation; Foundation Fighting Blindness","keywords":"RNA Helicase A; RIG-I; Small nuclear RNA; RNA; Gene knockdown; Biology; Spliceosome; RNA-dependent RNA polymerase; Virology; RNA silencing; Sendai virus; Cell biology; IRF3; Helicase; RNA splicing; RNA interference; Virus; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007386336,0.0002170844,0.0001437763,0.0001103213,0.0001105999,0.0002000602,0.0000721863,0.0001659456,0.001618619],"category_scores_gemma":[0.00006757065,0.0000767465,0.0001940203,0.0000475515,0.0001338387,0.0001053685,0.0001765068,0.0002592803,0.000381563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001599327,"about_ca_system_score_gemma":0.00008912469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002050388,"about_ca_topic_score_gemma":0.0002771869,"domain_scores_codex":[0.9999324,0.00001063804,0.000006440633,0.00001396391,0.00001637,0.00002025885],"domain_scores_gemma":[0.9999439,0.00000444181,0.00001721096,0.000005377657,0.000006314386,0.00002288341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001258781,0.000008197814,0.0008954506,0.00001182826,0.000002210213,0.0001169659,0.00001036579,0.00001984251,0.9979835,0.00004874699,0.00002466227,0.000752371],"study_design_scores_gemma":[0.00001841155,0.0002484175,0.03022072,0.00000801034,0.00001581313,0.001530442,0.00007793863,0.0009345473,0.9652486,0.0001541089,0.001538421,0.000004618625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982148,0.0002937206,0.0006528393,0.00003084102,0.000007274924,0.000003730488,0.00008703594,0.00004009042,0.0006695499],"genre_scores_gemma":[0.9990119,0.00007116495,0.0002318131,0.00001111001,0.000002721763,0.000002976323,0.0001049375,0.000005295255,0.0005580035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618619,"threshold_uncertainty_score":0.005414844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01520897043279391,"score_gpt":0.2316488341016121,"score_spread":0.2164398636688182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}