{"id":"W2505532605","doi":"10.1016/j.cell.2016.07.004","title":"GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":569,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Heart, Lung, and Blood Institute; Lundbeckfonden; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; G protein-coupled receptor; Arrestin; G protein; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002639775,0.0002117065,0.0001666607,0.00004164586,0.0001069395,0.0000342705,0.0002547307,0.0001646491,0.0008022624],"category_scores_gemma":[0.0001204507,0.0001494118,0.0001041741,0.0000699853,0.00005968784,0.000005831871,0.0001044367,0.00006937973,0.00008045626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001971444,"about_ca_system_score_gemma":0.00009056497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001222664,"about_ca_topic_score_gemma":0.000003780709,"domain_scores_codex":[0.9986577,0.00007745538,0.0002475024,0.0004281306,0.0001726975,0.0004165387],"domain_scores_gemma":[0.9993271,0.00001569783,0.000085175,0.0003169555,0.000115299,0.0001398091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005018026,0.00003923349,0.00006131394,0.00003472244,0.00001160539,0.000006982611,0.00002986571,0.000005567324,0.9981103,0.0001334142,0.0004735117,0.001043279],"study_design_scores_gemma":[0.000688974,0.000232004,0.00001649951,0.00004780641,0.000007007594,0.000002116477,0.0001067794,0.00001996795,0.9799799,0.0005660816,0.01806797,0.0002649156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887408,0.0002875786,0.008793449,0.0002605653,0.00009198036,0.0005667094,0.00001333832,0.00004037803,0.001205222],"genre_scores_gemma":[0.9902245,0.0000123096,0.003357858,0.00007960008,0.0004600384,0.0001025096,0.00004625573,0.00004510166,0.005671863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01813045,"threshold_uncertainty_score":0.8784211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169600201774006,"score_gpt":0.2176857256503909,"score_spread":0.2059897236326508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}