{"id":"W2505532605","doi":"10.1016/j.cell.2016.07.004","title":"GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":569,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Heart, Lung, and Blood Institute; Lundbeckfonden; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; G protein-coupled receptor; Arrestin; G protein; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490641,0.0004111477,0.0003101894,0.0003027742,0.0003539865,0.0006734424,0.0003302711,0.0002938179,0.002266092],"category_scores_gemma":[0.0002052447,0.0002055591,0.000295096,0.0001542902,0.0002404356,0.0004367062,0.0004740639,0.0009714308,0.001553188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008713818,"about_ca_system_score_gemma":0.0003692711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005979993,"about_ca_topic_score_gemma":0.001271644,"domain_scores_codex":[0.9998368,0.00002139321,0.000009719066,0.00003224883,0.0000425134,0.00005717226],"domain_scores_gemma":[0.9998335,0.00002916782,0.00002561713,0.00002699517,0.00002226933,0.00006244731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074384,0.00001527977,0.00009027595,0.00001908516,0.000004533599,0.00008415704,0.000008966987,0.0000465074,0.9980515,0.0008371853,0.0001551364,0.0005799685],"study_design_scores_gemma":[0.00003446203,0.00009665373,0.004952509,0.000007038132,0.00001409469,0.0005005889,0.00003817448,0.002519061,0.9869523,0.0003394242,0.0045389,0.000006784325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804826,0.002946164,0.007970878,0.0007925039,0.0001230511,0.00008310952,0.0007221372,0.0004059141,0.006473644],"genre_scores_gemma":[0.9905687,0.000940434,0.002409376,0.0001396307,0.00004634508,0.00003713888,0.000626224,0.00005131117,0.005180802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266092,"threshold_uncertainty_score":0.007580817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169600201774006,"score_gpt":0.2176857256503909,"score_spread":0.2059897236326508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}