{"id":"W2505539351","doi":"10.1186/s13059-016-1030-0","title":"An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":789,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Aging; University at Buffalo; MedStar Health Research Institute; Wake Forest University; University of Pittsburgh; U.S. Department of Health and Human Services; National Institutes of Health; Ohio State University; National Heart, Lung, and Blood Institute; Brigham and Women's Hospital; National Cancer Institute","keywords":"Epigenetics; Demography; Biology; Mortality rate; Disease; Physiology; Ethnic group; Life expectancy; Medicine; Gerontology; Internal medicine; Genetics; Population; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005121222,0.0001298109,0.0001411978,0.0004398337,0.0002434983,0.0003298039,0.0001612368,0.0001303175,0.001706972],"category_scores_gemma":[0.001074257,0.00006943537,0.0001996621,0.0004593477,0.0001497908,0.0001386001,0.0002316283,0.0001595347,0.0001107197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001185578,"about_ca_system_score_gemma":0.0002508512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002297238,"about_ca_topic_score_gemma":0.003852638,"domain_scores_codex":[0.9998531,0.00004769037,0.000009316254,0.00004636053,0.00002076198,0.00002274841],"domain_scores_gemma":[0.9996062,0.00008332243,0.0001382135,0.00004379872,0.00007994934,0.00004852179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003685998,0.00004998126,0.9639161,0.00003222696,0.0001702962,0.00006305716,0.0002934838,0.0001227798,0.02090407,0.0002952008,0.0002855332,0.01349865],"study_design_scores_gemma":[0.000003283287,0.00008967624,0.9962522,0.000004251119,0.00006207528,0.00008638608,0.0001706713,0.0005102021,0.002173924,0.0001401098,0.0005040468,0.000003234843],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961686,0.0002594937,0.001760345,0.00007326088,0.00001500263,0.00001602219,0.0008893408,0.00001731804,0.0008005976],"genre_scores_gemma":[0.9979125,0.00006346892,0.001287014,0.0000429905,0.000007437027,0.00002310221,0.0002632154,0.000005679925,0.0003945638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002297238,"threshold_uncertainty_score":0.005710363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204599034083154,"score_gpt":0.2815035904373481,"score_spread":0.2694576000965165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}