{"id":"W2505545269","doi":"10.1182/blood.v116.21.1763.1763","title":"Mocetinostat (MGCD0103), An Isotype-Selective Histone Deacetylase (HDAC) Inhibitor, Produces Clinical Responses In Relapsed/Refractory Hodgkin Lymphoma (HL): Update From a Phase II Clinical Study","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; Cohort; Internal medicine; Adverse effect; Population; Gastroenterology; Refractory (planetary science); Phases of clinical research; Tolerability; Progressive disease; Surgery; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001836158,0.0003356871,0.0008138671,0.0002648348,0.000130311,0.0005049427,0.0002719028,0.0002856432,0.001447587],"category_scores_gemma":[0.0006707343,0.0001496219,0.0004075275,0.0003266899,0.0002458531,0.0002493799,0.0001396112,0.0009544815,0.0003276296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004080289,"about_ca_system_score_gemma":0.0004269691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004229362,"about_ca_topic_score_gemma":0.001247391,"domain_scores_codex":[0.9997405,0.0001202781,0.0000249906,0.00002872365,0.00004774379,0.00003766615],"domain_scores_gemma":[0.9994453,0.0002092575,0.0001345786,0.00003689493,0.00006307059,0.0001108829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1022866,0.01302634,0.08140412,0.002346929,0.001564343,0.0003976892,0.0003963224,0.002263238,0.1162629,0.0003970819,0.008993247,0.6706612],"study_design_scores_gemma":[0.1212505,0.511382,0.2579292,0.0005887971,0.002421728,0.002974368,0.0002580512,0.003790097,0.05111808,0.0004209838,0.04777684,0.00008938243],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705282,0.02254361,0.000895971,0.0003464936,0.00005625015,0.001026653,0.001086243,0.0001097135,0.003406921],"genre_scores_gemma":[0.9848272,0.00909093,0.001461371,0.0007469207,0.00009467557,0.0003723013,0.002236148,0.00002392787,0.00114665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001836158,"threshold_uncertainty_score":0.00971061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822597794993485,"score_gpt":0.3921089692585946,"score_spread":0.3638829913086598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}