{"id":"W2505657961","doi":"10.1111/mmi.13467","title":"Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in <i>Trypanosoma brucei</i>","year":2016,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile; Biotechnology and Biological Sciences Research Council; Institute of Infection and Immunity; Instituto de Salud Carlos III; Medical Research Council; Federación Española de Enfermedades Raras","keywords":"Trypanosoma brucei; Biology; Thymidine kinase; Enzyme; Thymidine; Cell cycle; Biochemistry; Kinase; Cell biology; Cell; Genetics; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003375125,0.0001595097,0.0001289257,0.0000830215,0.0001283734,0.0002353045,0.0001761704,0.0001586244,0.0004734726],"category_scores_gemma":[0.00009322262,0.0001197043,0.0001078881,0.0001001918,0.0002091131,0.0001914773,0.00009086676,0.0002524165,0.000142649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793165,"about_ca_system_score_gemma":0.0001189935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004634519,"about_ca_topic_score_gemma":0.0004965161,"domain_scores_codex":[0.9999795,0.000002449507,0.00000137632,0.000006827553,0.000005990996,0.000003871746],"domain_scores_gemma":[0.9999547,0.000006962931,0.00001948516,0.000004220035,0.000006333482,0.000008348524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007750362,0.000009636318,0.0004424696,0.00004459367,0.000004212165,0.0001392467,0.00002460788,0.0003047134,0.9974144,0.0002269501,0.00003107564,0.00128057],"study_design_scores_gemma":[0.00007443619,0.0004768673,0.06282347,0.00002353991,0.00007254654,0.002527449,0.0001236898,0.008054381,0.9128286,0.00107201,0.01189121,0.00003182238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930514,0.004079816,0.001653445,0.00007642469,0.00001671359,0.00000596703,0.000137187,0.00003698604,0.0009420635],"genre_scores_gemma":[0.9968919,0.001138369,0.001161204,0.00002187067,0.000008638942,0.000005431159,0.0003133428,0.000008596002,0.0004506228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004734726,"threshold_uncertainty_score":0.001583934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006202109076795955,"score_gpt":0.2565818692158563,"score_spread":0.2503797601390603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}