{"id":"W2505666614","doi":"10.1016/s1470-2045(16)30313-8","title":"Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study","year":2016,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":498,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Calgary; Queen's University; University of Toronto; BC Cancer Agency","funders":"National Health and Medical Research Council; National Institute for Health and Care Research; Canadian Cancer Society Research Institute; Medical Research Council; National Cancer Institute; Krebsliga Schweiz; Cancer Research UK","keywords":"Temozolomide; Medicine; Glioma; Internal medicine; Radiation therapy; Chemotherapy; Oncology; Oligodendroglioma; Surgery; Gastroenterology; Astrocytoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001765375,0.001664705,0.002583201,0.0005014968,0.0003193403,0.0009545152,0.0009076499,0.00146737,0.005010992],"category_scores_gemma":[0.00130428,0.0006124355,0.001708136,0.0006084928,0.001351258,0.0009985442,0.0004172678,0.002799067,0.0009516525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009524085,"about_ca_system_score_gemma":0.001213943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001833134,"about_ca_topic_score_gemma":0.003607015,"domain_scores_codex":[0.9993817,0.0003812725,0.00002587208,0.00007804925,0.00003712212,0.00009602528],"domain_scores_gemma":[0.9992151,0.0002535734,0.0001616327,0.00007206024,0.00003219259,0.0002654124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9734677,0.008468039,0.0003982629,0.0004031672,0.0006103595,0.00002683014,0.0000684425,0.0004424011,0.002400351,0.0001063071,0.0007560672,0.01285203],"study_design_scores_gemma":[0.8932217,0.1029042,0.00200013,0.00002508505,0.0003919625,0.00002674574,0.0000341193,0.000366482,0.0003312144,0.0001636849,0.0005166559,0.00001783039],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937754,0.001857275,0.0004296777,0.000397602,0.0002738829,0.00151833,0.0006493445,0.00005769989,0.001040807],"genre_scores_gemma":[0.9879038,0.002918299,0.001290844,0.0008775923,0.0003867791,0.002489232,0.0009497292,0.00004246198,0.003141285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005010992,"threshold_uncertainty_score":0.01676345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562643958390778,"score_gpt":0.3888392104313845,"score_spread":0.3332127708474767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}