{"id":"W2506065586","doi":"10.1016/j.mcn.2016.07.002","title":"Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes","year":2016,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Tropomyosin receptor kinase B; Neuroprotection; Neuroscience; Biology; Neurotrophin; Neurodegeneration; Calpain; Status epilepticus; Low-affinity nerve growth factor receptor; Neurotrophic factors; Receptor; Epilepsy; Internal medicine; Medicine; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800643,0.0001350989,0.0001230874,0.00008094581,0.0000571808,0.00001710816,0.0001257089,0.00007143738,0.000006456709],"category_scores_gemma":[0.0003337001,0.00009678521,0.00004170879,0.0002513983,0.0002035624,0.00001208407,0.00008707037,0.00004174418,8.733575e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008227358,"about_ca_system_score_gemma":0.00009318344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002431247,"about_ca_topic_score_gemma":0.00002271948,"domain_scores_codex":[0.9988784,0.00009874581,0.0002082694,0.0004312256,0.0001929931,0.0001904086],"domain_scores_gemma":[0.9995278,0.00001402279,0.00008126819,0.000209348,0.00008386512,0.00008373787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006235849,0.0000782198,0.002126945,0.00002518348,0.000002008525,0.00001537161,0.00001952396,0.00003483546,0.9957317,0.0001178105,0.0000179944,0.001768011],"study_design_scores_gemma":[0.0005681696,0.0002534774,0.002969848,0.00002274381,0.000006424667,0.00001942779,0.00001650081,0.0001351168,0.9948264,0.0001739007,0.0008723628,0.0001356014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729192,0.0004339188,0.02611728,0.0001392665,0.000064029,0.0002099147,0.000010809,0.000009814458,0.00009578136],"genre_scores_gemma":[0.9991595,0.0001163194,0.00005605276,0.0002711811,0.00002012638,0.00002032079,0.00001005142,0.00001273715,0.0003337691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02624026,"threshold_uncertainty_score":0.3946786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006993813810633251,"score_gpt":0.2093545285617626,"score_spread":0.2023607147511294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}