{"id":"W2506162896","doi":"10.1159/000446475","title":"When Is an Endophenotype Useful to Detect Association to a Disease? Exploring the Relationships between Disease Status, Endophenotype and Genetic Polymorphisms","year":2016,"lang":"en","type":"article","venue":"Human Heredity","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Endophenotype; Locus (genetics); Allele; Disease; Genetics; Biology; Medicine; Internal medicine; Neuroscience; Cognition; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03427314,0.001019151,0.00204899,0.002126042,0.0006395135,0.002651646,0.001244437,0.002058651,0.00199928],"category_scores_gemma":[0.0864908,0.0004929352,0.001619868,0.001864336,0.00332117,0.002564388,0.002511649,0.001509723,0.0004250215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003099562,"about_ca_system_score_gemma":0.0009503895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008780483,"about_ca_topic_score_gemma":0.001009219,"domain_scores_codex":[0.9716336,0.0219859,0.001192137,0.002579962,0.002089405,0.0005190232],"domain_scores_gemma":[0.8978243,0.08145173,0.006498083,0.01039324,0.00258026,0.001252398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001820161,0.0001839147,0.9126659,0.0003305978,0.001396855,0.000853222,0.0006740916,0.002913366,0.01462752,0.005765682,0.0004219202,0.05834678],"study_design_scores_gemma":[0.0002681591,0.001896984,0.8668465,0.0003849716,0.00180154,0.004765616,0.001391615,0.02914867,0.01103817,0.07758695,0.004682747,0.0001879869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.840087,0.002378828,0.1478098,0.00372567,0.0001727185,0.0002354386,0.001105863,0.000178898,0.004305765],"genre_scores_gemma":[0.9648221,0.0004989638,0.03339144,0.0004988011,0.00009132381,0.0001565114,0.0002029687,0.00004609864,0.0002917594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03427314,"threshold_uncertainty_score":0.1812558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0766884189978016,"score_gpt":0.2778648155353139,"score_spread":0.2011763965375123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}