{"id":"W2506218841","doi":"10.1002/pros.23235","title":"Metformin Elicits Antitumor Effects and Downregulates the Histone Methyltransferase Multiple Myeloma SET Domain (MMSET) in Prostate Cancer Cells","year":2016,"lang":"en","type":"article","venue":"The Prostate","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"DU145; Metformin; Gene knockdown; Prostate cancer; Cancer research; PI3K/AKT/mTOR pathway; Biology; Medicine; LNCaP; Endocrinology; Cancer; Cell culture; Internal medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000736645,0.0002261205,0.0002516091,0.0002079142,0.0001386918,0.0001824056,0.000122092,0.0001499881,0.001002349],"category_scores_gemma":[0.00006901257,0.00009114716,0.0002460535,0.0001966868,0.00008658349,0.00007437224,0.0001180921,0.000304498,0.0002010015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230464,"about_ca_system_score_gemma":0.0001957759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006489296,"about_ca_topic_score_gemma":0.001351689,"domain_scores_codex":[0.9999304,0.000006102069,0.000006144546,0.00001155369,0.0000296042,0.00001621728],"domain_scores_gemma":[0.9999558,0.000006477114,0.00001597371,0.000004226661,0.000007488253,0.00001008664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000120618,0.0000282868,0.000506627,0.00004861483,0.000009445154,0.00002816035,0.000006440692,0.00008373041,0.9975508,0.00002935191,0.00005013331,0.001537925],"study_design_scores_gemma":[0.00002028814,0.0004497089,0.01500312,0.000005184047,0.00003068763,0.0001773739,0.00002502782,0.0008145573,0.9808147,0.00002004784,0.002634364,0.000004888271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948128,0.002196247,0.001263252,0.00006618178,0.00003326699,0.00002239489,0.0006741913,0.00007502797,0.0008565849],"genre_scores_gemma":[0.9951203,0.001117187,0.001109117,0.00003559251,0.000007804038,0.0000246728,0.001091127,0.00001100646,0.001483224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002349,"threshold_uncertainty_score":0.003353179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005332539621106727,"score_gpt":0.2446158838044381,"score_spread":0.2392833441833314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}