{"id":"W2506218841","doi":"10.1002/pros.23235","title":"Metformin Elicits Antitumor Effects and Downregulates the Histone Methyltransferase Multiple Myeloma SET Domain (MMSET) in Prostate Cancer Cells","year":2016,"lang":"en","type":"article","venue":"The Prostate","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University Health Network; University of Toronto; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada","keywords":"DU145; Metformin; Gene knockdown; Prostate cancer; Cancer research; PI3K/AKT/mTOR pathway; Biology; Medicine; LNCaP; Endocrinology; Cancer; Cell culture; Internal medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006749855,0.0002684347,0.0002684641,0.00004309193,0.000154035,0.00003707175,0.0002595462,0.000071293,0.00001901412],"category_scores_gemma":[0.00005219111,0.0001273683,0.00007327433,0.0001398356,0.0003292379,0.0000151295,0.0001032033,0.0001135651,0.00001020736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002890917,"about_ca_system_score_gemma":0.00007924989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002227716,"about_ca_topic_score_gemma":0.0005833098,"domain_scores_codex":[0.998417,0.0002428494,0.0002686601,0.0004151868,0.00016108,0.0004952897],"domain_scores_gemma":[0.9992008,0.0001156272,0.00009311037,0.0004445453,0.00005705181,0.00008883728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002809409,0.00002592136,0.001155653,0.0000748505,0.0000601809,0.000007272004,0.001026169,0.00001758268,0.8829815,0.00004072321,0.0006767969,0.1136524],"study_design_scores_gemma":[0.001981395,0.0001158893,0.004407246,0.00007412367,0.00004379328,0.000007071974,0.00009723461,0.00001780306,0.9106306,0.000629291,0.08174041,0.0002551201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8922994,0.1057452,0.00005267917,0.000494627,0.0001921408,0.0009403236,0.0002257446,0.00001459385,0.00003527688],"genre_scores_gemma":[0.9396412,0.05839979,0.0001200232,0.0005733432,0.0001250756,0.0004087946,0.00002318196,0.00003990366,0.0006686976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1133973,"threshold_uncertainty_score":0.5193929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005332539621106727,"score_gpt":0.2446158838044381,"score_spread":0.2392833441833314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}