{"id":"W2506257347","doi":"10.1002/cyto.b.21389","title":"Performance Characteristics of a Non‐Fluorescent Aerolysin‐Based Paroxysmal Nocturnal Hemoglobinuria (PNH) Assay for Simultaneous Evaluation of PNH Neutrophils and PNH Monocytes by Flow Cytometry, Following Published PNH Guidelines","year":2016,"lang":"en","type":"article","venue":"Cytometry Part B Clinical Cytometry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"Alexion Pharmaceuticals","keywords":"Paroxysmal nocturnal hemoglobinuria; Flow cytometry; Coefficient of variation; Limits of agreement; Immunology; Cytometry; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003770871,0.0007284117,0.0003648618,0.0007914603,0.0002849202,0.000525273,0.0005821253,0.0009921177,0.0009833711],"category_scores_gemma":[0.005206095,0.0002103487,0.0003965605,0.0004547806,0.0003821148,0.0002296146,0.0003681672,0.0004725962,0.0007227114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102169,"about_ca_system_score_gemma":0.0003720403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008049913,"about_ca_topic_score_gemma":0.0009131617,"domain_scores_codex":[0.9942174,0.002146171,0.0004501042,0.00101644,0.001953112,0.0002167358],"domain_scores_gemma":[0.9955923,0.002418915,0.0005958833,0.0003300419,0.0009354698,0.0001272949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001348486,0.0003802915,0.04939175,0.0002349911,0.0001545738,0.0001147817,0.000445353,0.001617719,0.9199902,0.0002050137,0.000589697,0.02552712],"study_design_scores_gemma":[0.00005010436,0.003054908,0.1043998,0.00005753605,0.000218154,0.001501911,0.0001228678,0.02064938,0.8675557,0.0001238636,0.002195318,0.00007055437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902097,0.002547665,0.09148314,0.000170255,0.0000788868,0.0002552719,0.0006777787,0.0006865399,0.002003417],"genre_scores_gemma":[0.934153,0.0005977469,0.06156722,0.0001643619,0.0000378865,0.0003407117,0.001376863,0.0000754159,0.001686915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003770871,"threshold_uncertainty_score":0.01994252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07136135191042835,"score_gpt":0.3749508891331344,"score_spread":0.303589537222706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}