{"id":"W2506322793","doi":"10.1093/ecco-jcc/jjw133","title":"Pharmacokinetics and Exposure-response Relationship of Golimumab in Patients with Moderately-to-Severely Active Ulcerative Colitis: Results from Phase 2/3 PURSUIT Induction and Maintenance Studies","year":2016,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"Janssen Research and Development","keywords":"Golimumab; Ulcerative colitis; Pharmacokinetics; Medicine; Pancolitis; Internal medicine; Trough Concentration; Gastroenterology; Pharmacology; Rheumatoid arthritis; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574649,0.0001233323,0.0002020469,0.00007837544,0.00005404991,0.00002170797,0.00004830587,0.00006544503,0.000002270689],"category_scores_gemma":[0.0004245622,0.00008701296,0.00002112011,0.00004774024,0.0001700112,0.00003616145,0.00004630083,0.00007749834,1.526012e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003791526,"about_ca_system_score_gemma":0.00009314904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008842017,"about_ca_topic_score_gemma":0.00005411141,"domain_scores_codex":[0.998985,0.0001858452,0.0003611971,0.0001826719,0.0001490482,0.0001362503],"domain_scores_gemma":[0.9989236,0.0001046948,0.0002944999,0.00008726987,0.0004652364,0.0001247118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9581938,0.0003010868,0.01788674,0.00003940952,0.0003514047,0.0001701078,0.002733306,0.000032763,0.003379149,0.000130935,0.0004354918,0.01634581],"study_design_scores_gemma":[0.01173245,0.001272251,0.9800371,0.0002070975,0.00004481559,0.00001471902,0.0004359227,0.000004431402,0.005570963,0.0003488697,0.0002135293,0.0001178578],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986177,0.0002102914,0.00008032392,0.0002545158,0.00005174121,0.0002246688,0.0005380644,0.000001367347,0.00002133],"genre_scores_gemma":[0.9992335,0.0003437698,0.0001951979,0.00006651787,0.00005827248,0.000008561145,0.00000650626,0.000010173,0.00007751395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9621503,"threshold_uncertainty_score":0.3548285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598689130708424,"score_gpt":0.2758971476071947,"score_spread":0.2599102563001105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}