{"id":"W2507008765","doi":"10.1158/1538-7445.am2016-281","title":"Abstract 281: Bendamustine has the biochemical properties of an alkylating agent that synergizes with nucleoside analogues in chronic lymphocytic leukemia","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"George & Fay Yee Centre for Healthcare Innovation; University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Chronic lymphocytic leukemia; Pentostatin; Nucleoside analogue; Bendamustine; Chlorambucil; Fludarabine; Cladribine; Medicine; Cancer research; Programmed cell death; Leukemia; Nucleoside; Pharmacology; Apoptosis; Immunology; Biology; Chemotherapy; Lymphoma; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654274,0.0004282923,0.0003249739,0.0002674331,0.0001285457,0.0002120003,0.0001841917,0.0003275774,0.00251516],"category_scores_gemma":[0.0001234514,0.000134269,0.0002256458,0.0001988186,0.0001244497,0.0001620035,0.0001885075,0.0003745572,0.0005959634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002549605,"about_ca_system_score_gemma":0.0001703639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004661197,"about_ca_topic_score_gemma":0.0008124801,"domain_scores_codex":[0.9998677,0.00003462819,0.00001232227,0.00001688442,0.00003973081,0.00002880302],"domain_scores_gemma":[0.9999317,0.00001571052,0.00001222289,0.000005494837,0.00001242859,0.00002244988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000921989,0.0001184284,0.0005780587,0.0001221595,0.00001480401,0.0001147788,0.00001301947,0.0002543026,0.9910347,0.00006388727,0.0001544415,0.006609531],"study_design_scores_gemma":[0.0002885932,0.006761283,0.01561815,0.00002706271,0.00005726597,0.001561901,0.00002196832,0.0009203124,0.9615927,0.00006559386,0.01307407,0.00001093588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835203,0.009704899,0.0008200196,0.0001851966,0.00005008261,0.00007026281,0.0005662839,0.00004232315,0.00504062],"genre_scores_gemma":[0.9912938,0.002585133,0.001306884,0.00008528778,0.00002814827,0.00003709511,0.001284428,0.00001426414,0.003365099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00251516,"threshold_uncertainty_score":0.00841409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1433099689428818,"score_gpt":0.3701723221243809,"score_spread":0.2268623531814992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}