{"id":"W2507306980","doi":"10.1038/nmeth.3995","title":"A proposal for validation of antibodies","year":2016,"lang":"en","type":"article","venue":"Nature Methods","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":645,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute on Drug Abuse","keywords":"Antibody; Computer science; Computational biology; Medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008443005,0.00008394788,0.0002411669,0.00009661594,0.00003578077,0.00000371436,0.00007146091,0.0001754547,0.0001012107],"category_scores_gemma":[0.001047574,0.00004182228,0.0001292616,0.000110812,0.00009924081,0.00004241605,0.00003232171,0.0001516572,0.000005143798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001679699,"about_ca_system_score_gemma":0.0001292006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005109647,"about_ca_topic_score_gemma":8.217146e-7,"domain_scores_codex":[0.9991637,0.0001161855,0.0001707993,0.0001605078,0.0002172324,0.0001716142],"domain_scores_gemma":[0.9987938,0.0006367695,0.00005626123,0.0001528064,0.0002969892,0.00006340078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008050661,0.00006473326,0.008098812,0.0002862946,0.00007772447,0.000002628876,0.00005358585,6.063922e-8,0.7663702,0.01506671,0.002708035,0.2064662],"study_design_scores_gemma":[0.0007586768,0.0003396931,0.01103038,0.0001185662,0.00003935428,0.00001994354,0.0000104664,0.00002184881,0.9126247,0.0103765,0.06459359,0.00006633002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7175425,0.004540327,0.2173967,0.04232699,0.001008327,0.002111074,0.0001907744,0.000111949,0.01477134],"genre_scores_gemma":[0.1766181,0.0001199663,0.8133273,0.0001614453,0.0003220283,0.00002482137,0.00001649259,0.00001533419,0.009394496],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.5959306,"threshold_uncertainty_score":0.1705463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04220168583204635,"score_gpt":0.4691830622997801,"score_spread":0.4269813764677337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}