{"id":"W2507393168","doi":"10.1042/bsr20160344","title":"Differential renal effects of candesartan at high and ultra-high doses in diabetic mice–potential role of the ACE2/AT2R/Mas axis","year":2016,"lang":"en","type":"article","venue":"Bioscience Reports","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"Candesartan; Albuminuria; Endocrinology; Internal medicine; Medicine; Angiotensin II; Kidney; Diabetic nephropathy; Renin–angiotensin system; Diabetes mellitus; Receptor; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002562367,0.0001806571,0.0005412587,0.0001184748,0.00009141392,0.000008621011,0.0001068585,0.00008882244,0.0000144402],"category_scores_gemma":[0.0006042487,0.00009088318,0.0001117579,0.0002883933,0.0007605866,0.00006782006,0.000149248,0.00005913435,8.167269e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008891089,"about_ca_system_score_gemma":0.0001084316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006589711,"about_ca_topic_score_gemma":0.0001563574,"domain_scores_codex":[0.9979581,0.00008308178,0.0005723565,0.0004410074,0.0006218001,0.0003236432],"domain_scores_gemma":[0.998686,0.0001584395,0.0004557371,0.0004830059,0.0001159476,0.0001008921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004022433,0.00005000029,0.3093431,0.00004439076,0.00002110919,0.00007923321,0.0001950769,3.723605e-7,0.6894708,0.00001025552,0.00004295784,0.0007024613],"study_design_scores_gemma":[0.0004104085,0.0001374107,0.5325119,0.0004511319,0.00005485125,0.0001846401,0.0000155645,0.000002057759,0.4660936,0.0000511412,0.00002538696,0.00006192633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977433,0.0005351828,0.00001738708,0.0003803765,0.0007095302,0.0005271593,0.000006407417,0.00001476304,0.00006591248],"genre_scores_gemma":[0.9994171,0.00007973774,0.0000607522,0.00001381163,0.00007062641,0.00001357486,7.929734e-7,0.00001169172,0.000331956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2233772,"threshold_uncertainty_score":0.3706108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003965258702614491,"score_gpt":0.2061143241682836,"score_spread":0.2021490654656691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}