{"id":"W2507426012","doi":"10.1186/s40064-016-2912-z","title":"Association between SLCO1B1 −521T>C and −388A>G polymorphisms and risk of statin-induced adverse drug reactions: A meta-analysis","year":2016,"lang":"en","type":"review","venue":"SpringerPlus","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SLCO1B1; Medicine; Drug; Meta-analysis; Statin; Genome-wide association study; Pharmacology; Pharmacogenomics; Adverse effect; Drug reaction; Bioinformatics; Internal medicine; Pharmacogenetics; Genotype; Single-nucleotide polymorphism; Gene; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003443106,0.0005389232,0.006058404,0.0007054787,0.0001466657,0.00002629243,0.0001282512,0.0004444985,0.0001436153],"category_scores_gemma":[0.0006579265,0.0003599782,0.003569347,0.0007572125,0.0000568476,0.000114974,0.0001297933,0.0005739937,0.00002848893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004428246,"about_ca_system_score_gemma":0.0004052003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002401434,"about_ca_topic_score_gemma":0.000149704,"domain_scores_codex":[0.9958206,0.0007328372,0.001286327,0.0007714739,0.0009648744,0.0004239313],"domain_scores_gemma":[0.995949,0.0005271086,0.001832336,0.001114468,0.0002369196,0.0003402147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00001410876,0.00004274502,0.001525617,0.00684539,0.3960673,0.00001772602,0.0001242578,1.766314e-7,0.0000055946,0.00004945253,0.00007837342,0.5952292],"study_design_scores_gemma":[0.000605743,0.00006670628,0.003483765,0.001024836,0.5845212,0.00001592989,0.00001768428,0.000001329951,0.00001277153,0.00002370665,0.409929,0.0002972936],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003456229,0.9935606,0.0001252209,0.0001442146,0.0001094955,0.001570865,0.0004855553,0.00005791448,0.0004899417],"genre_scores_gemma":[0.001919343,0.9942505,0.0006595748,0.00001934016,0.0003994263,0.0001712093,0.00008085935,0.00006482792,0.002434961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.594932,"threshold_uncertainty_score":0.9998852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05492479557516053,"score_gpt":0.3233935569912904,"score_spread":0.2684687614161299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}