{"id":"W2507426012","doi":"10.1186/s40064-016-2912-z","title":"Association between SLCO1B1 −521T>C and −388A>G polymorphisms and risk of statin-induced adverse drug reactions: A meta-analysis","year":2016,"lang":"en","type":"review","venue":"SpringerPlus","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"SLCO1B1; Medicine; Drug; Meta-analysis; Statin; Genome-wide association study; Pharmacology; Pharmacogenomics; Adverse effect; Drug reaction; Bioinformatics; Internal medicine; Pharmacogenetics; Genotype; Single-nucleotide polymorphism; Gene; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00867928,0.002777564,0.0129665,0.004164001,0.0005870308,0.002775961,0.001593946,0.001921404,0.00238021],"category_scores_gemma":[0.0126036,0.001276034,0.04731641,0.004809812,0.000492528,0.001079511,0.001147255,0.001649711,0.0002371321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001824637,"about_ca_system_score_gemma":0.001982164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00701604,"about_ca_topic_score_gemma":0.01164461,"domain_scores_codex":[0.9952483,0.00231892,0.001041466,0.0006147462,0.0005507135,0.0002258549],"domain_scores_gemma":[0.9933783,0.004717324,0.000973733,0.0002542078,0.0005404316,0.0001358818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.005676979,0.00005549924,0.01078879,0.06921029,0.9025255,0.0002326686,0.00006031094,0.001065228,0.000505869,0.00007350477,0.0004093956,0.009395959],"study_design_scores_gemma":[0.0004940212,0.0001832001,0.00562179,0.002328902,0.9902046,0.00009200349,0.00002103355,0.0003650106,0.00009998092,0.00009909242,0.000475212,0.00001526956],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02606296,0.971546,0.0008516727,0.0002953293,0.0001897737,0.0002154404,0.0004555468,0.00003923124,0.0003440094],"genre_scores_gemma":[0.4714412,0.5206297,0.003299634,0.00106167,0.0005008522,0.0008115231,0.001381593,0.00004502615,0.0008287285],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0129665,"threshold_uncertainty_score":0.045901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05492479557516053,"score_gpt":0.3233935569912904,"score_spread":0.2684687614161299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}