{"id":"W2507444523","doi":"10.1016/j.neuroscience.2016.08.014","title":"Contribution of synaptic plasticity in the insular cortex to chronic pain","year":2016,"lang":"en","type":"review","venue":"Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Long-term potentiation; Glutamatergic; Neuroscience; Anterior cingulate cortex; Chronic pain; Insular cortex; Neurotransmission; Synaptic plasticity; Sensitization; Cortex (anatomy); Psychology; Neuroplasticity; Medicine; Glutamate receptor; Cognition; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004224004,0.0008692974,0.001261569,0.001261577,0.0002410445,0.001049342,0.0008362999,0.001031339,0.002856735],"category_scores_gemma":[0.0005901634,0.0002424255,0.0004488415,0.001461258,0.0006161002,0.001119048,0.0007590211,0.001582608,0.001196326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005551658,"about_ca_system_score_gemma":0.001230396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00148837,"about_ca_topic_score_gemma":0.002902905,"domain_scores_codex":[0.9999034,0.00001152334,0.00001684117,0.00002181095,0.00003324942,0.00001312804],"domain_scores_gemma":[0.9997953,0.00009267427,0.00003457833,0.000007083421,0.00005206097,0.00001833933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001360074,0.00005673961,0.000199111,0.01821987,0.0001121548,0.0002269104,0.0000437233,0.0003709932,0.003066346,0.003274846,0.01291575,0.9613776],"study_design_scores_gemma":[0.00005157211,0.0001993073,0.003326445,0.008827062,0.0004477508,0.0026423,0.0001542016,0.0003099483,0.001537868,0.008876979,0.9735729,0.00005359613],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000145352,0.998515,0.0001370065,0.0002006666,0.0001539658,0.000003443586,0.00001653907,0.000004131728,0.0008238435],"genre_scores_gemma":[0.0007379872,0.9985488,0.0001228157,0.00009400592,0.0001535466,0.000003225264,0.00001575609,7.685963e-7,0.0003231514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002856735,"threshold_uncertainty_score":0.009556711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03670846485881447,"score_gpt":0.3355037617073938,"score_spread":0.2987952968485793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}