{"id":"W2507603703","doi":"10.1016/j.bpj.2015.11.2535","title":"Mitochondrial Targeting of Apollo-NADP+ Reveals that Palmitate-Induced Toxicity in Beta-Cells Involves a Drop in Mitochondrial NADPH/NADP+ Redox State","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Mitochondrion; Reactive oxygen species; Biochemistry; Thioredoxin; Oxidative stress; Mitochondrial ROS; Redox; Glutathione; Biology; Chemistry; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555785,0.0002358296,0.0002546313,0.0001344833,0.0002416552,0.0005386683,0.000373651,0.000434378,0.001792666],"category_scores_gemma":[0.0001344605,0.0001543351,0.0003008784,0.0002694509,0.0003461041,0.0003579586,0.0002672218,0.001312474,0.0006280967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004711183,"about_ca_system_score_gemma":0.0001958982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009659813,"about_ca_topic_score_gemma":0.0009258928,"domain_scores_codex":[0.9998717,0.00001090298,0.00001052363,0.00003184895,0.00003559115,0.00003932535],"domain_scores_gemma":[0.9998816,0.00001970933,0.0000273967,0.00002574131,0.00001571543,0.00002973762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005374957,0.00003523738,0.0003105185,0.00003305441,0.000008651135,0.0001044584,0.00002452456,0.00004847844,0.9974509,0.000196025,0.00007096226,0.001179598],"study_design_scores_gemma":[0.00003973605,0.0001429215,0.006563863,0.000005767416,0.0000181863,0.0004447709,0.00008500298,0.001454162,0.9895923,0.0001655958,0.001482171,0.000005570526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986511,0.0007536788,0.00923398,0.0005352848,0.00008608111,0.00001608729,0.0007428618,0.0001338147,0.001987173],"genre_scores_gemma":[0.9940892,0.0003916333,0.002610915,0.0001545174,0.00001366736,0.00002258089,0.0007359628,0.00005741802,0.001924002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792666,"threshold_uncertainty_score":0.005997062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02459295816431848,"score_gpt":0.2625176917618392,"score_spread":0.2379247335975207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}