{"id":"W2507857874","doi":"10.1038/srep31628","title":"Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"European Commission; Centre International de Recherche sur le Cancer; World Health Organization","keywords":"Adenocarcinoma; KRAS; Somatic cell; Biology; Somatic evolution in cancer; Lung cancer; Cancer research; Germline mutation; Cancer; Pathology; Mutation; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783017,0.00009039738,0.0001621891,0.001330452,0.0001472094,0.0003776979,0.0001340381,0.0002117785,0.00118905],"category_scores_gemma":[0.0007661183,0.00008085754,0.0001265649,0.0005832618,0.0001200181,0.0001678056,0.0001755187,0.0001739467,0.0001764449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304826,"about_ca_system_score_gemma":0.00008545546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009678528,"about_ca_topic_score_gemma":0.001587409,"domain_scores_codex":[0.9999017,0.0000164414,0.00001072177,0.00003212816,0.00002007027,0.00001901377],"domain_scores_gemma":[0.9995956,0.0001351426,0.0001098674,0.00003394296,0.00007525766,0.00005011625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000397893,0.00004163039,0.7823519,0.0001082374,0.0000733374,0.0009405997,0.0003484354,0.0003350215,0.1876359,0.0001497495,0.0001729194,0.02744435],"study_design_scores_gemma":[0.000002214129,0.00009306843,0.9896197,0.000006816513,0.00003722103,0.001866033,0.000165158,0.000739795,0.006502673,0.0001658596,0.0007974899,0.000004043024],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978099,0.000550853,0.0006661086,0.00002437252,0.000002452731,0.000008410751,0.0003476778,0.00001232837,0.0005778006],"genre_scores_gemma":[0.9984956,0.0002642235,0.0005395018,0.00001632342,0.000004939133,0.000007257162,0.0004618597,0.000004701843,0.0002056335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001330452,"threshold_uncertainty_score":0.003977776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008610268636495508,"score_gpt":0.2641786658283461,"score_spread":0.2555683971918506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}