{"id":"W2507857874","doi":"10.1038/srep31628","title":"Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"European Commission; Centre International de Recherche sur le Cancer; World Health Organization","keywords":"Adenocarcinoma; KRAS; Somatic cell; Biology; Somatic evolution in cancer; Lung cancer; Cancer research; Germline mutation; Cancer; Pathology; Mutation; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002979091,0.0001112042,0.0001647417,0.00007946687,0.00005229322,0.00004173907,0.0001339413,0.00007461182,0.00003791165],"category_scores_gemma":[0.0003778954,0.00008819392,0.00004965059,0.0001232161,0.00008211369,0.000004980677,0.0002182556,0.0000334332,0.000003534693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006326557,"about_ca_system_score_gemma":0.0003415399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001316611,"about_ca_topic_score_gemma":0.0006058143,"domain_scores_codex":[0.9985847,0.00002037251,0.0004304027,0.0005857847,0.0001572279,0.0002214543],"domain_scores_gemma":[0.9989045,0.00002850108,0.000285362,0.0005558496,0.0001273438,0.00009842401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002152722,0.000020675,0.2578302,0.0000102925,0.000009005495,0.00003144366,0.00009689374,0.000006057448,0.734511,0.000002679012,0.001402847,0.006057313],"study_design_scores_gemma":[0.000160419,0.00004075631,0.1843878,0.0001709027,0.00001159354,0.000006424505,0.00001836467,0.000004773319,0.8113489,0.0001325214,0.003582003,0.0001355335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963779,0.0008253235,0.0003100557,0.0001223341,0.001902301,0.0002828222,0.0000601579,0.000004328047,0.0001147621],"genre_scores_gemma":[0.9987751,0.0000876317,0.000506247,0.00005060809,0.0001921254,0.0000449611,0.00009957626,0.00001614446,0.0002276617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07683785,"threshold_uncertainty_score":0.3596444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008610268636495508,"score_gpt":0.2641786658283461,"score_spread":0.2555683971918506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}