{"id":"W2507917983","doi":"10.1038/srep31285","title":"Organization of Nucleotides in Different Environments and the Formation of Pre-Polymers","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero dello Sviluppo Economico; National Research Council Canada; Ontario Ministry of Economic Development and Innovation; McMaster University","keywords":"Nucleotide; Polymerization; RNA; Phosphodiester bond; Ribose; Chemistry; Polymer; Molecule; Crystallography; Monomer; Nucleic acid; Biophysics; Biochemistry; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008529711,0.0001672962,0.0001239621,0.0001153439,0.0002406917,0.0003178171,0.0001937866,0.0002565019,0.0006164535],"category_scores_gemma":[0.0002599727,0.0001871578,0.0001256769,0.0001087874,0.0003331466,0.0003968473,0.0002295645,0.0004432305,0.0001352786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002079979,"about_ca_system_score_gemma":0.0001956473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005671489,"about_ca_topic_score_gemma":0.0009850693,"domain_scores_codex":[0.9999065,0.00001184841,0.000003697116,0.00002520323,0.00002976341,0.00002284546],"domain_scores_gemma":[0.9998626,0.0000510044,0.00003816255,0.000008766729,0.00001489,0.00002457241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007381262,0.00003180096,0.00102296,0.00006325702,0.00000686364,0.0001193989,0.00008975198,0.001862254,0.9946092,0.0007345781,0.00002001072,0.001366029],"study_design_scores_gemma":[0.00001049672,0.0001838743,0.005990113,0.000009254563,0.00001304806,0.0001356748,0.0001305228,0.01165398,0.9802387,0.0005353597,0.001083932,0.00001501829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974594,0.0002693196,0.001446579,0.00002045388,0.000004354608,0.000007869168,0.00002441879,0.0000167112,0.0007509464],"genre_scores_gemma":[0.9976561,0.0002160031,0.001739361,0.000009751193,0.000001499665,0.000009570533,0.0000385776,0.000005900583,0.0003232569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006164535,"threshold_uncertainty_score":0.002062261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004619117265950948,"score_gpt":0.1905271959244893,"score_spread":0.1859080786585384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}