{"id":"W2507950939","doi":"10.1158/1078-0432.ccr-16-1192","title":"MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Deutsches Krebsforschungszentrum; McGill University","keywords":"Microphthalmia-associated transcription factor; Melanoma; MEK inhibitor; MAPK/ERK pathway; Cancer research; Gene knockdown; Medicine; Antibody-drug conjugate; Trametinib; Dabrafenib; Antibody; Monoclonal antibody; Cell culture; Immunology; Biology; Vemurafenib; Signal transduction; Tyrosinase; Metastatic melanoma; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340571,0.0002467092,0.0003122607,0.0001974339,0.0001265173,0.0002532266,0.0001333393,0.0001826632,0.00228263],"category_scores_gemma":[0.0001535564,0.0001262354,0.0002860459,0.000132149,0.00009248091,0.0001222429,0.0001297917,0.0003586528,0.0003839724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767946,"about_ca_system_score_gemma":0.0001948469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009165398,"about_ca_topic_score_gemma":0.002157438,"domain_scores_codex":[0.9998795,0.00001295107,0.000008001846,0.00003198837,0.00004413397,0.00002347897],"domain_scores_gemma":[0.9999467,0.00000798022,0.00001680208,0.000007748975,0.000007970859,0.00001277495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005070199,0.0001311795,0.00297651,0.0001231899,0.00003930654,0.00004764427,0.00001605046,0.0003270312,0.9882646,0.00003722807,0.000346771,0.007183382],"study_design_scores_gemma":[0.0001299408,0.003370308,0.05768664,0.00002061935,0.0001056332,0.001053607,0.00004725554,0.002330177,0.9261615,0.00005798899,0.009026828,0.000009437867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99654,0.001045122,0.0004522427,0.00005009645,0.00001899221,0.00005827401,0.0008837247,0.00007083379,0.0008808047],"genre_scores_gemma":[0.9951199,0.0007104618,0.0008746758,0.00004587106,0.000005714369,0.00005263513,0.001852727,0.00001517104,0.001322969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00228263,"threshold_uncertainty_score":0.00763613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08395417958845613,"score_gpt":0.447579595077615,"score_spread":0.3636254154891588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}