{"id":"W2507988253","doi":"10.1155/2016/9240103","title":"Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time‐of‐Flight Mass Spectrometry (UPLC/Q‐TOF‐MS/MS)","year":2016,"lang":"en","type":"article","venue":"Evidence-based Complementary and Alternative Medicine","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Science Foundation of Liaoning Province","keywords":"CYP1A2; CYP3A4; Microsome; Metabolic pathway; Cytochrome P450; Hydroxylation; CYP2E1; Chemistry; Metabolism; Chromatography; CYP2D6; Biochemistry; Drug metabolism; CYP2C19; CYP2B6; Metabolomics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499793,0.000392242,0.0002463737,0.0004882288,0.0001875805,0.0001972979,0.000106856,0.0002678937,0.0008964601],"category_scores_gemma":[0.0001751114,0.0001160468,0.0004181116,0.0002395276,0.0001194382,0.000227595,0.0001444561,0.0002744031,0.0003795423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001534427,"about_ca_system_score_gemma":0.0003009874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006853209,"about_ca_topic_score_gemma":0.0007225967,"domain_scores_codex":[0.9999204,0.00001109742,0.000007413211,0.00002652761,0.00002329746,0.00001140442],"domain_scores_gemma":[0.9999105,0.00001465594,0.0000308341,0.000008157742,0.0000229621,0.00001277168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568053,0.00002655557,0.002633987,0.00007188106,0.00002755778,0.0001820127,0.00001827017,0.00007286778,0.9899431,0.00007722752,0.00004280842,0.006746712],"study_design_scores_gemma":[0.00002828033,0.000495731,0.05834487,0.00001524341,0.0001200741,0.001635889,0.00005306295,0.002630351,0.9311242,0.0001847609,0.005348561,0.00001889389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9710669,0.006934172,0.01843525,0.0001562985,0.00003941292,0.00009285923,0.001318083,0.0001558238,0.001801209],"genre_scores_gemma":[0.9674713,0.004176461,0.02190925,0.0001781058,0.00004230383,0.00009777875,0.003068363,0.00003861437,0.003017772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008964601,"threshold_uncertainty_score":0.002998948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599023084153593,"score_gpt":0.2600103303326496,"score_spread":0.2440200994911137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}