{"id":"W2507988253","doi":"10.1155/2016/9240103","title":"Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time‐of‐Flight Mass Spectrometry (UPLC/Q‐TOF‐MS/MS)","year":2016,"lang":"en","type":"article","venue":"Evidence-based Complementary and Alternative Medicine","topic":"Bioactive natural compounds","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Science Foundation of Liaoning Province","keywords":"CYP1A2; CYP3A4; Microsome; Metabolic pathway; Cytochrome P450; Hydroxylation; CYP2E1; Chemistry; Metabolism; Chromatography; CYP2D6; Biochemistry; Drug metabolism; CYP2C19; CYP2B6; Metabolomics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005650521,0.0002421047,0.0004589632,0.0001987826,0.00008288227,0.000007316604,0.0003383998,0.00006948612,0.0001077402],"category_scores_gemma":[0.0001136677,0.0001449406,0.000091935,0.0003964728,0.000627407,0.0000749893,0.0000959328,0.0001079731,5.839211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001073235,"about_ca_system_score_gemma":0.00003882513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000701532,"about_ca_topic_score_gemma":0.000005978882,"domain_scores_codex":[0.9981159,0.0002714088,0.0006493626,0.0003778565,0.000392048,0.0001934516],"domain_scores_gemma":[0.9984266,0.0001350829,0.000765146,0.0003250574,0.0002781375,0.00007003847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003431494,0.00005242413,0.007542082,0.00008947488,0.000231208,1.837676e-7,0.00008397714,5.532185e-7,0.9908325,0.0003262341,0.00006939953,0.0004288143],"study_design_scores_gemma":[0.001194371,0.000417191,0.06048709,0.0003502363,0.0001661247,0.000001758537,0.00004041843,0.0001071595,0.9349035,0.00005380718,0.002132155,0.0001462041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714949,0.02380719,0.002026338,0.001665343,0.0001549081,0.0003980613,0.0004366105,0.00000619522,0.00001049322],"genre_scores_gemma":[0.9912493,0.007898108,0.0001524784,0.0002728741,0.0001756704,0.00001958874,0.0001710205,0.00001460574,0.00004633898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05592902,"threshold_uncertainty_score":0.5910506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599023084153593,"score_gpt":0.2600103303326496,"score_spread":0.2440200994911137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}