{"id":"W2508007408","doi":"10.1007/978-94-007-7745-3_41-1","title":"Sirtuins as Markers of Bone Disease: A Focus on Osteoarthritis and Osteoporosis","year":2016,"lang":"en","type":"book-chapter","venue":"Exposure and Health","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Epigenetics; Biology; Cell biology; Bone remodeling; Osteoarthritis; Senescence; SIRT6; Osteoporosis; Histone; Inflammation; Cancer research; NAD+ kinase; Sirtuin; Medicine; Immunology; Endocrinology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008101399,0.001290669,0.001385836,0.002148638,0.0003353575,0.001750403,0.0008585479,0.001871696,0.005827519],"category_scores_gemma":[0.0007428504,0.0003923839,0.0006348021,0.002186586,0.001226281,0.002637387,0.0011354,0.00280412,0.002741865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008646272,"about_ca_system_score_gemma":0.000817086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167071,"about_ca_topic_score_gemma":0.00495494,"domain_scores_codex":[0.9997496,0.00004848416,0.00002122314,0.00004944306,0.0001148524,0.00001631875],"domain_scores_gemma":[0.9997409,0.0001629703,0.00001763719,0.0000109821,0.00004987049,0.00001771777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001511922,0.0001208174,0.0003636278,0.004509959,0.0000936919,0.0002678085,0.0004541072,0.0005385613,0.007345099,0.07210805,0.1631474,0.7508997],"study_design_scores_gemma":[0.000016026,0.00007669214,0.0007122624,0.0009592503,0.00004891628,0.0005928358,0.0001186603,0.000140019,0.0006914573,0.02981702,0.9668012,0.00002561821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002330714,0.985194,0.0007670155,0.002145265,0.002057858,0.000005243492,0.00003873034,0.00002190288,0.009536777],"genre_scores_gemma":[0.003247724,0.9531993,0.001836569,0.00293225,0.004624146,0.00002426078,0.0000818856,0.00002371456,0.03403],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005827519,"threshold_uncertainty_score":0.01949501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627449452150874,"score_gpt":0.2754247346821834,"score_spread":0.2591502401606746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}