{"id":"W2508036785","doi":"10.1016/j.neuropharm.2016.08.004","title":"Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties","year":2016,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Medical Research Council","keywords":"NMDA receptor; Long-term potentiation; AMPA receptor; Excitatory postsynaptic potential; Pharmacology; Chemistry; Sigma-1 receptor; Glutamate receptor; Dizocilpine; Ifenprodil; Hippocampal formation; Neuroscience; Receptor; Biophysics; Biology; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001859797,0.0005227405,0.0004619112,0.0003413085,0.000535424,0.00009538374,0.001206547,0.0001175184,0.001653739],"category_scores_gemma":[0.0004356889,0.0003115906,0.0001251126,0.0009737642,0.001456162,0.0005975559,0.0003569351,0.0006320663,0.00194425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055194,"about_ca_system_score_gemma":0.0004645108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189977,"about_ca_topic_score_gemma":0.000003287914,"domain_scores_codex":[0.9947512,0.0009833417,0.0004444822,0.001738107,0.0007193791,0.001363513],"domain_scores_gemma":[0.9976327,0.0008223671,0.0002169931,0.0005292027,0.00011357,0.0006851239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002364154,0.0003334452,0.0005877027,0.00001524066,0.00001694786,0.000518714,0.00008603659,0.000005580728,0.9649854,0.00008244514,0.02601627,0.004988051],"study_design_scores_gemma":[0.003515372,0.001580178,0.0005347516,0.00001706502,0.00003217124,0.0002433977,0.000008368166,0.00002392068,0.863263,0.00001761767,0.1303949,0.0003693172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837734,0.00004494879,0.00008780506,0.01024824,0.003176758,0.00108052,0.0000345436,0.0003629529,0.001190813],"genre_scores_gemma":[0.9626425,0.001065555,0.00004046986,0.01517953,0.0005079664,0.0001768081,3.863757e-7,0.0001093314,0.02027745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1043786,"threshold_uncertainty_score":0.9999336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07337620623572459,"score_gpt":0.3298508214769786,"score_spread":0.256474615241254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}