{"id":"W2508109728","doi":"10.1161/circulationaha.116.023171","title":"Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1","year":2016,"lang":"en","type":"article","venue":"Circulation","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Colorado State University; U.S. Department of Defense","keywords":"Reprogramming; Downregulation and upregulation; Corepressor; Anaerobic glycolysis; Pulmonary hypertension; Medicine; Glycolysis; Molecular biology; Cancer research; Cell biology; Chemistry; Biology; Biochemistry; Endocrinology; Gene expression; Internal medicine; Metabolism; Cell; Repressor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558753,0.0001922788,0.0001397462,0.0001460507,0.0001789268,0.0001757015,0.0001357498,0.0002142558,0.0008878075],"category_scores_gemma":[0.0001521807,0.00009639611,0.000148581,0.00009238535,0.0002812124,0.0001032859,0.0001837071,0.0003236814,0.0002153008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052197,"about_ca_system_score_gemma":0.0001479217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006809089,"about_ca_topic_score_gemma":0.0008438472,"domain_scores_codex":[0.9998845,0.00002012424,0.000006850416,0.0000323218,0.00003081128,0.0000255648],"domain_scores_gemma":[0.9998568,0.00002265948,0.00005533921,0.00001272581,0.00001693138,0.00003551606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228011,0.00001153353,0.0007321755,0.00002501248,0.000002828897,0.00006495837,0.00001521541,0.00002885662,0.9983875,0.00004073295,0.00001955703,0.0005488321],"study_design_scores_gemma":[0.00003721273,0.0003641206,0.1129286,0.00001540473,0.000043601,0.001134633,0.000161848,0.002203786,0.8809368,0.0001423105,0.002021629,0.0000100983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994543,0.001100731,0.003041982,0.000104428,0.00001697413,0.00002509964,0.0002861205,0.00004771113,0.0008340739],"genre_scores_gemma":[0.9972895,0.0004175692,0.001269194,0.00004059135,0.000007990882,0.00002516901,0.0002012168,0.000007515557,0.0007412254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008878075,"threshold_uncertainty_score":0.00297004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075698382450064,"score_gpt":0.2606867113910761,"score_spread":0.2399297275665755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}