{"id":"W2508219633","doi":"10.1021/acsinfecdis.6b00110","title":"Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets","year":2016,"lang":"en","type":"review","venue":"ACS Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Excellence Research Chairs, Government of Canada","keywords":"Lipid bilayer fusion; Glycoprotein; Virology; Viral envelope; Biology; Glycosylation; Viral entry; Transmembrane protein; Hepatitis C virus; Computational biology; Function (biology); Virus; Cell biology; Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002687348,0.0005585331,0.0008140621,0.001166163,0.0002147485,0.0007216061,0.0004570738,0.0007460976,0.002489148],"category_scores_gemma":[0.0003098696,0.0002069232,0.0003452892,0.001072504,0.0002609536,0.0009008663,0.0003908536,0.0008484271,0.001603499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004145039,"about_ca_system_score_gemma":0.0007819493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007337081,"about_ca_topic_score_gemma":0.0009172654,"domain_scores_codex":[0.9999121,0.00001245018,0.00001382048,0.00001430047,0.00003427064,0.00001299301],"domain_scores_gemma":[0.9999059,0.00002935588,0.00001888928,0.000003535685,0.00003108024,0.0000112677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001017191,0.00007638276,0.0003081324,0.01832608,0.00006722665,0.0002840081,0.0000756562,0.0004897881,0.008541059,0.005251394,0.01708083,0.9493977],"study_design_scores_gemma":[0.00001079807,0.0001101081,0.001026589,0.001812628,0.00007614746,0.001253069,0.00006550519,0.0001034592,0.001789826,0.001535057,0.9921998,0.00001699595],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003234464,0.9982326,0.00009477519,0.0001662384,0.0001110375,0.000003288236,0.00002064425,0.000003950955,0.001043951],"genre_scores_gemma":[0.001190409,0.9977297,0.0001481385,0.00007866449,0.00006874633,0.000003654561,0.00003594986,7.952021e-7,0.0007438864],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002489148,"threshold_uncertainty_score":0.008327007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503406022918231,"score_gpt":0.3008262867050609,"score_spread":0.2857922264758786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}