{"id":"W2508219633","doi":"10.1021/acsinfecdis.6b00110","title":"Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets","year":2016,"lang":"en","type":"review","venue":"ACS Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Excellence Research Chairs, Government of Canada","keywords":"Lipid bilayer fusion; Glycoprotein; Virology; Viral envelope; Biology; Glycosylation; Viral entry; Transmembrane protein; Hepatitis C virus; Computational biology; Function (biology); Virus; Cell biology; Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113859,0.0004231301,0.001241831,0.0002354514,0.0002056,0.00005297396,0.00009858927,0.0002877665,0.0001600343],"category_scores_gemma":[0.0006860748,0.0002427198,0.0001501984,0.000293673,0.0002750381,0.0001493347,0.0003181513,0.0003803504,0.000008065149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009697882,"about_ca_system_score_gemma":0.0003515664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005803903,"about_ca_topic_score_gemma":0.0007420862,"domain_scores_codex":[0.9980962,0.0002550449,0.0004416054,0.0005127589,0.0003799905,0.0003143475],"domain_scores_gemma":[0.9986559,0.0002354721,0.0002725368,0.000465155,0.0001456793,0.0002252522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003752781,0.00005144614,0.1296425,0.008243203,0.0003070444,0.00002103407,0.00002007302,8.544808e-9,0.00004677133,0.00006583527,0.0004478389,0.8611167],"study_design_scores_gemma":[0.001871276,0.0008228064,0.1873667,0.01196381,0.002238759,0.0001809237,0.000003531233,0.000002000671,0.0001588549,0.0007461457,0.7941185,0.000526768],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06439364,0.9322867,0.00001204596,0.00004940314,0.0001963106,0.001611416,0.001100777,0.00005355807,0.0002961323],"genre_scores_gemma":[0.1606802,0.8386947,0.000007526637,0.0000634845,0.0002216253,0.00007338786,0.00005789167,0.0000575117,0.0001436952],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8605899,"threshold_uncertainty_score":0.9897828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503406022918231,"score_gpt":0.3008262867050609,"score_spread":0.2857922264758786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}