{"id":"W2508378848","doi":"10.1136/gutjnl-2015-311247","title":"PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury","year":2016,"lang":"en","type":"article","venue":"Gut","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Alberta Innovates - Health Solutions","keywords":"Mitochondrial fission; Hepatocyte; Liver injury; Programmed cell death; Hepatitis; Medicine; Pathogenesis; Immunology; Apoptosis; Pharmacology; Mitochondrion; Biology; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000629555,0.0001113139,0.0002361455,0.00005940397,0.00003591862,0.000007343893,0.0001028243,0.00006447325,0.0005552639],"category_scores_gemma":[0.0001073979,0.00006678262,0.0001276811,0.0001211268,0.0001679605,0.0001035621,0.00007793822,0.00006389169,0.0002327261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003195212,"about_ca_system_score_gemma":0.00009007726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001775487,"about_ca_topic_score_gemma":0.000002365616,"domain_scores_codex":[0.9992442,0.00003532056,0.0001873037,0.000144265,0.0001742252,0.0002147251],"domain_scores_gemma":[0.9992317,0.00007246951,0.00008016946,0.0003297671,0.0001293667,0.0001565516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001110103,0.0007792268,0.6161156,0.0001678007,0.0006294993,0.00004366113,0.0006256904,1.406847e-8,0.2693142,0.0001284921,0.009749065,0.1013367],"study_design_scores_gemma":[0.002455608,0.001032395,0.9259772,0.000320761,0.0004541445,0.000009009376,0.00008565428,0.00002992817,0.05381094,0.0001090653,0.01552777,0.0001874955],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978446,0.0003829579,0.00002652987,0.0005661985,0.00008301474,0.0003323884,0.0001063036,0.00006839846,0.0005896526],"genre_scores_gemma":[0.9970689,0.0007699517,0.0003194382,0.000206343,0.00006017239,0.00002776285,0.0000330754,0.00001552883,0.001498874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3098617,"threshold_uncertainty_score":0.6079751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01434488747880282,"score_gpt":0.2639861051692788,"score_spread":0.249641217690476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}