{"id":"W2508436450","doi":"10.1186/s12888-016-0989-0","title":"DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression","year":2016,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Dalhousie University; Montreal Neurological Institute and Hospital","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; Pfizer Canada; National Institutes of Health; Pfizer","keywords":"DNA methylation; CpG site; Epigenetics; Major depressive disorder; Autism spectrum disorder; Biology; Methylation; MECP2; Bipolar disorder; Genetics; Gene; Mood disorders; Psychology; Gene expression; Mood; Autism; Psychiatry; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467116,0.00013949,0.0001529905,0.00009323259,0.00007071163,0.00000753242,0.00008062051,0.0001896792,0.00001215026],"category_scores_gemma":[0.00008284076,0.00009133456,0.0000380634,0.0001089981,0.00004598136,0.000009091192,0.00007671388,0.00004506014,6.480689e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008972281,"about_ca_system_score_gemma":0.00006709055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004915843,"about_ca_topic_score_gemma":0.0004183692,"domain_scores_codex":[0.9990487,0.0001064044,0.0002378449,0.0003071616,0.0001364695,0.000163414],"domain_scores_gemma":[0.9994541,0.00002594502,0.000172022,0.0002426686,0.00005034306,0.00005492489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001192079,0.00005862042,0.514331,0.00001308036,0.000007238585,3.713554e-8,0.0000118002,0.000005095272,0.48447,0.000007153194,0.00001554805,0.0009612544],"study_design_scores_gemma":[0.001707355,0.000240642,0.5249639,0.00008280302,0.00001363488,8.285114e-7,0.00001673577,0.00001829402,0.4719521,0.0003856479,0.0004853217,0.0001327841],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799312,0.010371,0.00926011,0.00005256156,0.00009573321,0.0001595925,0.00003062316,0.000007367506,0.00009176882],"genre_scores_gemma":[0.9908771,0.0005197573,0.008313911,0.00001436893,0.0000895575,0.0000217891,0.00006121238,0.00002123948,0.00008107114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01251792,"threshold_uncertainty_score":0.3724515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005059811883103615,"score_gpt":0.2227652023618441,"score_spread":0.2177053904787405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}