{"id":"W2508524924","doi":"10.1097/md.0000000000004756","title":"First case report of an adrenocortical carcinoma caused by a BRCA2 mutation","year":2016,"lang":"en","type":"article","venue":"Medicine","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé","keywords":"Frameshift mutation; Loss of heterozygosity; Medicine; Adrenocortical carcinoma; Germline mutation; Mutation; Germline; Cancer research; Genetics; Allele; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385977,0.00009158225,0.0001462014,0.00002038782,0.00003893466,0.00000245663,0.00007383631,0.0000835599,0.0003674767],"category_scores_gemma":[0.0002146594,0.00005640315,0.0000347803,0.00003773734,0.0002313249,0.000003744131,0.00002581573,0.00002735093,0.000003783164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005561709,"about_ca_system_score_gemma":0.00002565556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006180262,"about_ca_topic_score_gemma":0.00007331266,"domain_scores_codex":[0.9991532,0.00002868166,0.0003398285,0.0002205052,0.0001338026,0.0001239869],"domain_scores_gemma":[0.9994017,0.00002787272,0.0001040529,0.0002453935,0.0001022195,0.0001187321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004188073,0.0008213695,0.01662484,0.00020367,0.0001661836,0.03267955,0.0007099416,0.000004566859,0.8690901,0.0005299702,0.02329005,0.05546089],"study_design_scores_gemma":[0.009077879,0.01021906,0.04671934,0.0001898738,0.0002022832,0.04434995,0.001816059,0.0001508953,0.8117611,0.0008325658,0.07396215,0.0007188395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962838,0.0002352986,0.0008537172,0.001932354,0.00008606178,0.00008186892,0.00001618032,0.000008208855,0.0005025436],"genre_scores_gemma":[0.9973918,0.00002528799,0.00008342088,0.0002683321,0.0002125348,0.000009705687,0.00007224435,0.00000886224,0.001927881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05732905,"threshold_uncertainty_score":0.4023612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131098877856444,"score_gpt":0.2765332010331086,"score_spread":0.2634233132474642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}