{"id":"W2508616096","doi":"10.1172/jci86437","title":"BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; University of Toronto; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; Wellcome Trust; Pfizer; Princess Margaret Cancer Foundation; National Institutes of Health; Ontario Genomics","keywords":"Adoptive immunotherapy; Immunotherapy; Bromodomain; Persistence (discontinuity); Adoptive cell transfer; Function (biology); Cancer research; Immunology; Biology; T cell; Computational biology; Immune system; Cell biology; Epigenetics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002672659,0.00009850824,0.0003866438,0.0001865518,0.00003213954,0.00001939881,0.00005022479,0.0001572314,0.0001569958],"category_scores_gemma":[0.0004194135,0.00006421496,0.0001463956,0.0001740544,0.0003137106,0.0005238177,0.00001511024,0.000373927,0.000005839534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009735835,"about_ca_system_score_gemma":0.0002259316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009631982,"about_ca_topic_score_gemma":0.000007826032,"domain_scores_codex":[0.9979256,0.0003445647,0.0009802633,0.0001727096,0.0004315112,0.0001453262],"domain_scores_gemma":[0.998206,0.0006812745,0.0005006778,0.0001200172,0.0003042727,0.0001878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003180202,0.0002085093,0.03141409,0.00004201181,0.00005786761,0.00002456628,0.000532445,0.00002699497,0.8835962,0.0002004665,0.0002197649,0.0804969],"study_design_scores_gemma":[0.03136184,0.01396876,0.4480221,0.003409217,0.0002017365,0.0002673872,0.001193921,0.003641739,0.3836129,0.1114581,0.002369186,0.0004931661],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911019,0.0004366297,0.004297529,0.003211032,0.0001660659,0.0001930763,0.000001587596,0.000007116275,0.0005851079],"genre_scores_gemma":[0.9943363,0.002298557,0.001861473,0.0004984392,0.0003468935,0.000003809266,0.000001889694,0.00001330202,0.0006393323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4999833,"threshold_uncertainty_score":0.261861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1278042311533566,"score_gpt":0.3737692853268149,"score_spread":0.2459650541734583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}