{"id":"W2508616096","doi":"10.1172/jci86437","title":"BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models","year":2016,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; University of Toronto; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; Novartis Pharma; Ontario Genomics Institute; Wellcome Trust; Pfizer; Princess Margaret Cancer Foundation; National Institutes of Health; Ontario Genomics","keywords":"Adoptive immunotherapy; Immunotherapy; Bromodomain; Persistence (discontinuity); Adoptive cell transfer; Function (biology); Cancer research; Immunology; Biology; T cell; Computational biology; Immune system; Cell biology; Epigenetics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004714954,0.0006473766,0.0005404763,0.0006320206,0.0002013612,0.0003548451,0.0004446988,0.000480954,0.001136039],"category_scores_gemma":[0.0001733214,0.0002283372,0.0003209283,0.0002490686,0.0003265911,0.0003756726,0.0002343889,0.001515281,0.0003174634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000327535,"about_ca_system_score_gemma":0.0002583429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003890331,"about_ca_topic_score_gemma":0.0007083457,"domain_scores_codex":[0.9996463,0.00007371855,0.0000293646,0.00005503843,0.00009576206,0.00009985903],"domain_scores_gemma":[0.9998368,0.00003125825,0.00004198542,0.00002417771,0.00001549605,0.00005022874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003072655,0.0004024868,0.00007114396,0.00003262987,0.000006981486,0.00002175445,0.00002277331,0.0001318455,0.9971269,0.00009891376,0.00005010656,0.00172714],"study_design_scores_gemma":[0.0000857696,0.002490142,0.0007738524,0.00000465325,0.00002545345,0.00009439859,0.00001295288,0.001327207,0.9941635,0.00005814835,0.000959889,0.000004024292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992584,0.001142058,0.004122017,0.0001145889,0.00005449819,0.0001039776,0.0001700064,0.0001981044,0.001510815],"genre_scores_gemma":[0.9936619,0.0007581504,0.002606116,0.00005771619,0.00002092105,0.0001128932,0.000304348,0.0000245084,0.002453446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136039,"threshold_uncertainty_score":0.003800392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1278042311533566,"score_gpt":0.3737692853268149,"score_spread":0.2459650541734583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}