{"id":"W2508645113","doi":"10.1016/j.phrs.2016.08.034","title":"Ligand autoradiographical quantification of histamine H 3 receptor in human dementia with Lewy bodies","year":2016,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Newfoundland and Labrador; Newcastle University; Parkinson's UK","keywords":"Dementia with Lewy bodies; Histamine H3 receptor; Radioligand; Dementia; Globus pallidus; Histamine; Receptor; Medicine; Psychosis; Neuroscience; Basal ganglia; Disease; Internal medicine; Psychology; Psychiatry; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001508402,0.0001203387,0.0002666193,0.0003430013,0.000163245,0.000009465198,0.0002881879,0.0001625858,0.004216636],"category_scores_gemma":[0.0001344806,0.00006727433,0.00004896899,0.000337827,0.001241955,0.00006076743,0.0001052925,0.0003712456,0.0001366469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006073594,"about_ca_system_score_gemma":0.00004699345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001156877,"about_ca_topic_score_gemma":0.00008470118,"domain_scores_codex":[0.998089,0.0005747899,0.0003382286,0.0003597262,0.0001346201,0.0005036153],"domain_scores_gemma":[0.9989831,0.0005126253,0.00007595582,0.00016635,0.0002154914,0.00004642357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004873714,0.0005345853,0.02193812,0.00002611222,0.00009718646,0.000008278711,0.00006890611,4.924155e-7,0.9640055,0.003275686,0.005349886,0.004207857],"study_design_scores_gemma":[0.003397355,0.001249662,0.06019728,0.00006833811,0.00003372306,0.000004239637,0.00007065693,0.000002747399,0.8322146,0.0002895956,0.1023007,0.0001710977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942283,0.002113212,0.000168578,0.001207016,0.0001002595,0.0003435558,0.00002453042,0.0000314099,0.001783132],"genre_scores_gemma":[0.99506,0.0005789658,0.00006445341,0.00001635046,0.00002608658,0.00007685374,0.000027086,0.000009572893,0.004140645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1317909,"threshold_uncertainty_score":0.9966937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08519187536683633,"score_gpt":0.3730481682213723,"score_spread":0.287856292854536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}