{"id":"W2508757001","doi":"10.1073/pnas.1604256113","title":"IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada; Canadian Child Health Clinician Scientist Program; American Association of Immunologists","keywords":"Immunology; Chronic infection; CD8; Immunity; Effector; Cytokine; Viral infection; Biology; Immune system; Virus; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982725,0.0002697624,0.0002330925,0.000154607,0.00009944409,0.0003300293,0.0001488327,0.0001715033,0.0005356312],"category_scores_gemma":[0.0001513194,0.0001214433,0.0001608057,0.00008064562,0.000246355,0.0001586202,0.0002880509,0.0004734313,0.0002892284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849007,"about_ca_system_score_gemma":0.0001715524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164541,"about_ca_topic_score_gemma":0.0003755355,"domain_scores_codex":[0.999863,0.00002148082,0.00001331464,0.00001818251,0.00002370673,0.00006021],"domain_scores_gemma":[0.9998876,0.00001437118,0.00003104143,0.00001812538,0.000009112587,0.00003986516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001564938,0.00002553728,0.0005434594,0.00001740356,0.000003614038,0.00004974194,0.00002502518,0.00006096411,0.9975547,0.00008639539,0.00003609624,0.00144065],"study_design_scores_gemma":[0.0001287375,0.001277855,0.04238914,0.00004276603,0.00004355024,0.001043048,0.0001801582,0.001886483,0.9478347,0.0003914125,0.004772268,0.00001005532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978023,0.0008381269,0.0005679737,0.00003375973,0.00001043028,0.000006459739,0.00006611272,0.00003960509,0.0006352174],"genre_scores_gemma":[0.9980234,0.0004113332,0.000460305,0.0000509771,0.00001066529,0.00001842875,0.0001626878,0.00001460695,0.0008477342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005356312,"threshold_uncertainty_score":0.001791894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0190763005476337,"score_gpt":0.2646436349857359,"score_spread":0.2455673344381022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}