{"id":"W2508827030","doi":"10.2147/dddt.s112181","title":"Pharmacokinetic profile of defibrotide in patients with renal impairment","year":2016,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec Rehabilitation Research Network","funders":"Jazz Pharmaceuticals","keywords":"Defibrotide; Medicine; Hepatic veno-occlusive disease; Pharmacokinetics; Dialysis; Cmax; Dosing; Hemodialysis; Internal medicine; Confidence interval; Gastroenterology; Urology; Surgery; Transplantation; Hematopoietic stem cell transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871599,0.0001094972,0.0001738096,0.00009943847,0.00001672417,0.000003060398,0.00002960233,0.00002227632,0.0001037712],"category_scores_gemma":[0.000002131474,0.00006037959,0.0000118288,0.00009501249,0.00003158344,0.00004191457,0.000004104338,0.00002978729,0.000007533671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003050026,"about_ca_system_score_gemma":0.00009841026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002219931,"about_ca_topic_score_gemma":6.944684e-7,"domain_scores_codex":[0.9992217,0.00004048937,0.0002294641,0.0001496783,0.0002141883,0.0001445185],"domain_scores_gemma":[0.999707,0.00006201082,0.00005679924,0.00007091846,0.00004674722,0.00005648837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003986248,0.0004924509,0.8544834,0.0001417394,0.00009641799,0.00001365941,0.003303756,0.000001343821,0.04260169,0.00002250507,0.0001475134,0.09470926],"study_design_scores_gemma":[0.009657248,0.0002498764,0.5302823,0.0004348202,0.000009260021,0.000003318027,0.00001649833,0.000003536472,0.4589128,0.00001580543,0.0003184478,0.0000961418],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950381,0.00009984124,0.003664118,0.0000883225,0.00001710423,0.0008701333,0.000001691128,0.00001519142,0.0002054822],"genre_scores_gemma":[0.9851255,0.0001376819,0.0143554,0.00004545042,0.00000598389,0.00006086751,0.000009930312,0.00001365451,0.0002455374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4163111,"threshold_uncertainty_score":0.2462208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435522791611445,"score_gpt":0.229222546916762,"score_spread":0.2148673190006475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}