{"id":"W2508827030","doi":"10.2147/dddt.s112181","title":"Pharmacokinetic profile of defibrotide in patients with renal impairment","year":2016,"lang":"en","type":"article","venue":"Drug Design Development and Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Quebec Rehabilitation Research Network","funders":"Jazz Pharmaceuticals","keywords":"Defibrotide; Medicine; Hepatic veno-occlusive disease; Pharmacokinetics; Dialysis; Cmax; Dosing; Hemodialysis; Internal medicine; Confidence interval; Gastroenterology; Urology; Surgery; Transplantation; Hematopoietic stem cell transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006415864,0.0002045929,0.0007895646,0.0001709509,0.0001916868,0.0003757841,0.0001088254,0.0002966057,0.000536897],"category_scores_gemma":[0.001851517,0.0001265869,0.0002819615,0.0002164165,0.00018202,0.000376572,0.0001553098,0.0004938097,0.000157778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280905,"about_ca_system_score_gemma":0.0002231258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134067,"about_ca_topic_score_gemma":0.0004434608,"domain_scores_codex":[0.9996812,0.00009947936,0.00003827091,0.00007352034,0.00007425514,0.00003329863],"domain_scores_gemma":[0.9990287,0.0002911113,0.0003379032,0.00007435386,0.00008399475,0.0001840165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05300787,0.002397099,0.8069481,0.0002158253,0.0005990281,0.001063835,0.0006235623,0.002057724,0.05105991,0.0001984012,0.0008018282,0.0810269],"study_design_scores_gemma":[0.001418807,0.04313409,0.9418212,0.00002648181,0.000284942,0.002275415,0.0001867035,0.003013268,0.004989536,0.0001791395,0.002632305,0.00003814166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984288,0.0007355743,0.0001908816,0.00004541712,0.000006244714,0.00002248263,0.0001028907,0.000008418438,0.0004594105],"genre_scores_gemma":[0.999265,0.0001885189,0.0001670352,0.00008835763,0.00001537094,0.00001283624,0.0001304582,0.000001715066,0.0001308086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007895646,"threshold_uncertainty_score":0.003393054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435522791611445,"score_gpt":0.229222546916762,"score_spread":0.2148673190006475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}