{"id":"W2508958722","doi":"10.1016/j.bmc.2016.08.053","title":"Synthesis and preclinical characterization of 1-(6′-deoxy-6′-[18F]fluoro-β-d-allofuranosyl)-2-nitroimidazole (β-6′-[18F]FAZAL) as a positron emission tomography radiotracer to assess tumor hypoxia","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Biodistribution; Tumor hypoxia; Positron emission tomography; In vivo; Nucleoside; Misonidazole; Nitroimidazole; Hypoxia (environmental); Nucleoside analogue; In vitro; Radiochemistry; Stereochemistry; Nuclear medicine; Biochemistry; Oxygen; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004256891,0.0005314894,0.0003213109,0.0004223464,0.000316653,0.000259718,0.0005797429,0.0004270522,0.001778922],"category_scores_gemma":[0.0002381822,0.0003778455,0.0003083081,0.0002803355,0.0002447636,0.0003269466,0.000160013,0.0005413149,0.0007376795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672893,"about_ca_system_score_gemma":0.0007075648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002309085,"about_ca_topic_score_gemma":0.004269264,"domain_scores_codex":[0.999864,0.00003037222,0.000007659611,0.00002729917,0.00002328888,0.00004742118],"domain_scores_gemma":[0.9998553,0.00001855645,0.00003232758,0.00002491353,0.00002659037,0.0000423707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005861689,0.0005788268,0.0002462821,0.00008803722,0.00002086989,0.0001284963,0.00006874594,0.0008604843,0.9886567,0.0003138961,0.0003762222,0.008075276],"study_design_scores_gemma":[0.0003794654,0.006594033,0.001901584,0.00001655394,0.00009989752,0.0005421526,0.0000297203,0.001157396,0.9764655,0.00007485412,0.01272157,0.00001723744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492361,0.006021677,0.03379699,0.000597171,0.0001079411,0.00147138,0.002452811,0.0003209243,0.005995063],"genre_scores_gemma":[0.9676559,0.00387245,0.01720055,0.0002150075,0.00004264469,0.0005610992,0.002132474,0.00006637883,0.008253466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309085,"threshold_uncertainty_score":0.005951107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289026165453815,"score_gpt":0.2591353361962045,"score_spread":0.2462450745416664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}