{"id":"W2509038340","doi":"10.1038/nchembio.2165","title":"Dual action antifungal small molecule modulates multidrug efflux and TOR signaling","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; University of Toronto; Ministry of Trade, Industry and Energy; National Cancer Institute; TD Bank","keywords":"Beauvericin; Efflux; Biology; Multiple drug resistance; Drug resistance; Antifungal drug; TOR signaling; ATP-binding cassette transporter; Drug discovery; Microbiology; Pharmacology; Signal transduction; Candida albicans; Transporter; Biochemistry; Genetics; Gene; Fusarium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001159646,0.0002658503,0.0002803558,0.0001810452,0.0002092178,0.0005874553,0.0002510307,0.0003939628,0.002274312],"category_scores_gemma":[0.0001451721,0.000136451,0.0001394729,0.0001245118,0.0002293982,0.0003084101,0.000193391,0.0007265921,0.0003295656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000410735,"about_ca_system_score_gemma":0.0001936067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001973041,"about_ca_topic_score_gemma":0.0005019131,"domain_scores_codex":[0.9999018,0.00001237411,0.000006076494,0.00001687115,0.00003066623,0.00003220126],"domain_scores_gemma":[0.9999357,0.00001137822,0.00001544529,0.000006730336,0.000008706206,0.00002193234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002241697,0.00001781417,0.00008093762,0.00001792009,0.000002674241,0.00004338034,0.000003844958,0.00002850843,0.9976904,0.0004450093,0.00008385009,0.001361498],"study_design_scores_gemma":[0.00003630462,0.0002176552,0.002059361,0.000003989624,0.00001264519,0.0001877947,0.00001938077,0.0008852976,0.993656,0.0001857532,0.002730139,0.000005685073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877182,0.002773565,0.00309184,0.0006025654,0.0001538695,0.00003282801,0.0003188101,0.0001537949,0.00515457],"genre_scores_gemma":[0.9956031,0.0007600555,0.001028172,0.00009866113,0.00002487491,0.00001882171,0.0001315901,0.00001232421,0.002322296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002274312,"threshold_uncertainty_score":0.007608294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008904344813139349,"score_gpt":0.2592716495884401,"score_spread":0.2503673047753007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}