{"id":"W2509038340","doi":"10.1038/nchembio.2165","title":"Dual action antifungal small molecule modulates multidrug efflux and TOR signaling","year":2016,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; University of Toronto; Ministry of Trade, Industry and Energy; National Cancer Institute; TD Bank","keywords":"Beauvericin; Efflux; Biology; Multiple drug resistance; Drug resistance; Antifungal drug; TOR signaling; ATP-binding cassette transporter; Drug discovery; Microbiology; Pharmacology; Signal transduction; Candida albicans; Transporter; Biochemistry; Genetics; Gene; Fusarium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021096,0.0001974332,0.0001916745,0.00002749779,0.00004349158,0.00001355049,0.0001395078,0.0009023058,0.00003199797],"category_scores_gemma":[0.0003492288,0.0001350685,0.00006874699,0.00004453552,0.0002307833,0.000004356136,0.0001379416,0.0002112935,0.000008954073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002052922,"about_ca_system_score_gemma":0.00002486782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003533238,"about_ca_topic_score_gemma":0.000003244623,"domain_scores_codex":[0.9988658,0.00005403689,0.0001888656,0.0005352558,0.00005210463,0.0003038847],"domain_scores_gemma":[0.9994509,0.00006542838,0.00007962064,0.0002393444,0.00007269386,0.00009196342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001358585,0.00002553427,0.01243786,0.00001389201,0.00004107038,0.000002198798,0.000004494351,1.272501e-7,0.9847607,0.0001174583,0.0003452781,0.0021155],"study_design_scores_gemma":[0.0005552666,0.00008298014,0.00309478,0.00002255891,0.00001307966,0.00002737692,0.000008178718,0.000008229098,0.9918149,0.0001408714,0.004023359,0.000208425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979063,0.0006847183,0.0005485446,0.0002893941,0.0002711317,0.0001092933,0.00003996269,0.00002659062,0.000124055],"genre_scores_gemma":[0.9970341,0.0001643195,0.001697809,0.0002195724,0.0005220908,0.000004171955,0.0001183305,0.00002232312,0.0002172513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009343079,"threshold_uncertainty_score":0.6959409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008904344813139349,"score_gpt":0.2592716495884401,"score_spread":0.2503673047753007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}