{"id":"W2509057822","doi":"10.18632/oncotarget.11680","title":"Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Western Hospital; University Health Network; SickKids Foundation","funders":"Canadian Institutes of Health Research","keywords":"Temozolomide; Medicine; Gene knockdown; Cancer research; Glioblastoma; Radiation therapy; Hexokinase; Chemotherapy; Cancer; Oncology; Radioresistance; Internal medicine; Cell culture; Bioinformatics; Biology; Metabolism; Glycolysis; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423003,0.0002891567,0.0006959023,0.0002362725,0.0001088071,0.000465599,0.0001748862,0.0002120349,0.001703565],"category_scores_gemma":[0.0001655438,0.0001245989,0.0002731997,0.0002560233,0.0001610776,0.0001901261,0.0001962652,0.0006224141,0.0004033081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004628034,"about_ca_system_score_gemma":0.0003918353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009220453,"about_ca_topic_score_gemma":0.002452137,"domain_scores_codex":[0.9999349,0.000007433885,0.000004097472,0.000007613528,0.00001724436,0.00002867846],"domain_scores_gemma":[0.999954,0.000005186477,0.00001167505,0.000003226822,0.000007726966,0.00001815788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0213555,0.004252714,0.01391124,0.00122404,0.0003499554,0.0005371842,0.0001609755,0.002312143,0.663096,0.0005488454,0.009945537,0.2823059],"study_design_scores_gemma":[0.004717199,0.06402238,0.1741283,0.000308545,0.001235614,0.002180743,0.0007324335,0.01125304,0.698339,0.001300377,0.04166277,0.0001195461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795756,0.01593566,0.0006757169,0.0006365838,0.0002570798,0.00008019467,0.0002403207,0.0001266162,0.002472246],"genre_scores_gemma":[0.9892012,0.008064666,0.0003763235,0.0002683348,0.00004877269,0.00006084499,0.0004038639,0.00001886221,0.001557121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001703565,"threshold_uncertainty_score":0.005698979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008239570100591518,"score_gpt":0.2755157269867919,"score_spread":0.2672761568862004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}