{"id":"W2509246155","doi":"10.7554/elife.16582","title":"Seipin is required for converting nascent to mature lipid droplets","year":2016,"lang":"en","type":"article","venue":"eLife","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; Wellcome Trust; Carnegie Mellon University; Villum Fonden; Howard Hughes Medical Institute; Biogen; Chinese Academy of Sciences; Canadian Institutes of Health Research; Wellcome; European Molecular Biology Organization; NIHR Cambridge Biomedical Research Centre; Strategiske Forskningsråd; G. Harold and Leila Y. Mathers Charitable Foundation","keywords":"Lipid droplet; Biology; Computational biology; Cell biology; Chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137056,0.0002262184,0.0002147544,0.0002088198,0.0001383649,0.0005950381,0.0001382462,0.0002259231,0.003094206],"category_scores_gemma":[0.000263557,0.0001075904,0.0002076204,0.0001285848,0.0001646517,0.0001610085,0.0002819472,0.0003646679,0.001066796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161779,"about_ca_system_score_gemma":0.0001645498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003226053,"about_ca_topic_score_gemma":0.000419801,"domain_scores_codex":[0.9998904,0.00001345666,0.00001390099,0.00003324087,0.00002999519,0.000018863],"domain_scores_gemma":[0.9998281,0.0000454708,0.00004102824,0.00002434536,0.00001588788,0.00004524898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002693604,0.000020976,0.001815354,0.00006550003,0.0000175739,0.0009158201,0.00002469473,0.0001416044,0.9913319,0.0005067473,0.0002696948,0.004620746],"study_design_scores_gemma":[0.00002400565,0.0001142137,0.01439845,0.00001620358,0.00002644714,0.003477488,0.0000559251,0.001438281,0.9591252,0.0003302186,0.02098594,0.000007542224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976014,0.004564845,0.01176449,0.0003000966,0.0001561359,0.00003278316,0.001833773,0.0003834021,0.004950454],"genre_scores_gemma":[0.9891604,0.001068077,0.003346338,0.00009236841,0.00001843157,0.0000173541,0.002388277,0.00003190185,0.00387682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003094206,"threshold_uncertainty_score":0.01035112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01228877585188025,"score_gpt":0.254517859635167,"score_spread":0.2422290837832868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}