{"id":"W2509261975","doi":"10.1038/srep32606","title":"Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Aging; Canadian Institutes of Health Research; National Cancer Institute; Conquer Cancer Foundation; National Institutes of Health; Prostate Cancer Canada; Movember Foundation; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Glutamine; Cancer cell; Glutathione; Glycolysis; Biochemistry; Cell culture; Carbohydrate metabolism; Glucose uptake; Reactive oxygen species; Metabolism; Chemistry; Cancer; Biology; Cell biology; Amino acid; Endocrinology; Enzyme; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006166571,0.0002120713,0.0002381679,0.0001276537,0.000170158,0.0004140911,0.0001566541,0.0001878193,0.000456814],"category_scores_gemma":[0.00007884262,0.0001131172,0.0001310373,0.0002416907,0.0002001878,0.0001595993,0.0002297127,0.0002869444,0.0001928267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003160766,"about_ca_system_score_gemma":0.0002527167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171426,"about_ca_topic_score_gemma":0.001713374,"domain_scores_codex":[0.9999223,0.00001238881,0.000009247639,0.00001997001,0.00002203146,0.00001395626],"domain_scores_gemma":[0.9999337,0.000006443357,0.00001872853,0.00001262786,0.000009541855,0.00001897134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126209,0.000006400168,0.0005363558,0.00002220266,0.000003494353,0.00006204637,0.00000993908,0.00005720004,0.9980425,0.0001236216,0.00003401366,0.0009895829],"study_design_scores_gemma":[0.00001425675,0.0001497687,0.02122728,0.000007855323,0.00001542645,0.0005700934,0.00005056331,0.0009470694,0.9714515,0.0002411024,0.005317313,0.000007737403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911838,0.002750451,0.00366504,0.0002092081,0.00003308595,0.0000155418,0.0006318467,0.0001029591,0.001408071],"genre_scores_gemma":[0.9950697,0.00117077,0.002099287,0.00005711632,0.000006167833,0.00001633326,0.0005165901,0.00001976302,0.001044222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171426,"threshold_uncertainty_score":0.002329171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466939120124706,"score_gpt":0.2569075635835313,"score_spread":0.2422381723822842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}