{"id":"W2509293655","doi":"10.1002/anie.201606006","title":"Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Joint Attosecond Science Laboratory; University of Ottawa","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Campylobacter jejuni; Glycobiology; Microbiology; Legionella pneumophila; Biology; Sialic acid; Biochemistry; Biosynthesis; Bacteria; Escherichia coli; Neuraminic acid; Virulence; Glycoconjugate; Bacterial cell structure; Glycan; Chemistry; Gene; Glycoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293535,0.0001227112,0.0001194308,0.00008008051,0.0000363959,0.00001758833,0.0002239025,0.0001433518,0.0004590836],"category_scores_gemma":[0.0002332616,0.00009281289,0.0001282754,0.00006458794,0.0001402218,0.00002112334,0.0001011759,0.00004711822,0.00003066276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004047704,"about_ca_system_score_gemma":0.00007542365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002262678,"about_ca_topic_score_gemma":0.00001489408,"domain_scores_codex":[0.9990153,0.00002678976,0.0002210383,0.0002777397,0.0002826914,0.0001764312],"domain_scores_gemma":[0.9993919,0.00002797667,0.0001111024,0.0001902194,0.00021123,0.00006761285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001992994,0.00007050264,0.0003673127,0.000007943343,0.00008399664,0.000003345258,0.00001537221,2.257217e-7,0.9877401,0.0000965624,0.009301185,0.002114144],"study_design_scores_gemma":[0.0007058089,0.0001095249,0.001310199,0.00004263423,0.00001046519,0.00002423694,0.00002036338,0.00000226118,0.9795437,0.0001323665,0.0179744,0.00012403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894869,0.0001089293,0.003449706,0.002236624,0.001162541,0.0001103792,0.000445586,0.00001624091,0.002983077],"genre_scores_gemma":[0.9955006,0.0002366525,0.000108247,0.00007681023,0.002594678,0.00002548508,0.000671236,0.00001556639,0.0007707531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008673218,"threshold_uncertainty_score":0.5026643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150460559289989,"score_gpt":0.2636011764543919,"score_spread":0.248555120525393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}